Investigations on the role of a lysozyme from the malaria vector Anopheles dirus during malaria parasite development

► We isolated, cloned and sequenced a full-length lysozyme from the Asian malaria vector, Anopheles dirus. ► AdLys c-1 transcripts were found in most tissues of adults and larvae. ► Gene silencing of AdLys c-1 resulted in reductions in the intensity and prevalence of Plasmodium berghei. A cDNA encod...

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Veröffentlicht in:	Developmental and comparative immunology 2012-01, Vol.36 (1), p.104-111
Hauptverfasser:	Lapcharoen, Parichat, Komalamisra, Narumon, Rongsriyam, Yupha, Wangsuphachart, Voranuch, Dekumyoy, Paron, Prachumsri, Jetsumon, Kajla, Mayur K., Paskewitz, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Amino Acid Sequence Animals Anopheles - embryology Anopheles - genetics Anopheles - growth & development Anopheles dirus Antimicrobial peptides calcium cecum complementary DNA Conserved Sequence - genetics Culicidae cysteine Cysteine - genetics Diptera double-stranded RNA Female females Gene Knockdown Techniques genes Insect Proteins - genetics Insect Proteins - metabolism Insect Vectors - embryology Insect Vectors - genetics Insect Vectors - growth & development insects Larva larvae lysozyme Lysozymes Malaria Malaria - parasitology Malaria - transmission Molecular Sequence Data molecular weight Muramidase - genetics Muramidase - metabolism Muramidase activity oocysts parasites Plasmodium Plasmodium berghei Plasmodium berghei - physiology reverse transcriptase polymerase chain reaction RNA interference salivary glands Salivary Glands - metabolism
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