Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

Despite the diverse biological pathways known to be regulated by ubiquitylation, global identification of substrates that are targeted for ubiquitylation has remained a challenge. To globally characterize the human ubiquitin-modified proteome (ubiquitinome), we utilized a monoclonal antibody that re...

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Veröffentlicht in:	Molecular cell 2011-10, Vol.44 (2), p.325-340
Hauptverfasser:	Kim, Woong, Bennett, Eric J., Huttlin, Edward L., Guo, Ailan, Li, Jing, Possemato, Anthony, Sowa, Mathew E., Rad, Ramin, Rush, John, Comb, Michael J., Harper, J. Wade, Gygi, Steven P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cullin Proteins - metabolism digestion Glycylglycine - genetics HCT116 Cells homeostasis Humans inhibition lysine Lysine - genetics monoclonal antibodies proteasome endopeptidase complex proteome Proteome - metabolism Proteomics temporal variation translation (genetics) trypsin ubiquitin Ubiquitin - metabolism ubiquitin-protein ligase Ubiquitination
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