Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

Quality control of endoplasmic reticulum proteins involves the identification and engagement of misfolded proteins, dislocation of the misfolded protein across the endoplasmic reticulum (ER) membrane, and ubiquitin-mediated targeting to the proteasome for degradation. Ancient ubiquitous protein 1 (A...

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Veröffentlicht in:	The Journal of biological chemistry 2011-10, Vol.286 (43), p.37602-37614
Hauptverfasser:	Klemm, Elizabeth J., Spooner, Eric, Ploegh, Hidde L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology E3 Ubiquitin Ligase Endoplasmic Reticulum (ER) Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism ER Quality Control HeLa Cells Humans Lipid Droplet Membrane Proteins Proteins - genetics Proteins - metabolism Ubiquitin Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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