Gadd45a Functions as a Promoter or Suppressor of Breast Cancer Dependent on the Oncogenic Stress

Gadd45a plays a pivotal role as a stress sensor that modulates cellular responses to various stress stimuli including oncogenic stress. We reported that the stress sensor Gadd45a gene functions as a tumor suppressor in Ras-driven breast tumorigenesis via increasing JNK-mediated apoptosis and p38-med...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-12, Vol.70 (23), p.9671-9681
Hauptverfasser:	TRONT, Jennifer S, YAJUE HUANG, FORNACE, Albert A, HOFFMAN, Barbara, LIEBERMANN, Dan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents beta Catenin - metabolism Biological and medical sciences Blotting, Western Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Female Gene Expression Regulation, Neoplastic Genes, myc - genetics Genes, myc - physiology Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Gynecology. Andrology. Obstetrics Immunohistochemistry Male Mammary gland diseases Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology Matrix Metalloproteinase 10 - genetics Matrix Metalloproteinase 10 - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neovascularization, Pathologic - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Proteins - physiology Pharmacology. Drug treatments RNA Interference Signal Transduction Tumor Burden Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology Tumors
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