Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia
To test the hypothesis that anterior cingulate cortex (ACC) subregions in patients with schizophrenia are metabolically different from those in healthy control subjects. This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty...
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description | To test the hypothesis that anterior cingulate cortex (ACC) subregions in patients with schizophrenia are metabolically different from those in healthy control subjects.
This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty-two patients with schizophrenia (13 male, nine female; 39.4 years ± 10.6 [standard deviation]) and 11 age- and sex-matched control subjects (seven male, four female; 35.5 years ± 10.7) underwent magnetic resonance (MR) imaging and three-dimensional 3-T voxel proton MR spectroscopy to measure absolute rostral and caudal ACC N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) concentrations. Exact Mann-Whitney test was used to compare patient data with control data, paired-sample Wilcoxon signed rank test was used to compare subregions within groups, and receiver operating characteristic curve analysis was used to assess sensitivity and specificity in diagnosis of schizophrenia.
There were no significant metabolic differences between patients and control subjects or between ACC subregions in control subjects. In patients, rostral ACC NAA and Cr concentrations were significantly lower than those in caudal ACC (6.2 mM ± 1.3 vs 7.1 mM ± 1.3, P < .01; 5.7 mmol/L ± 1.4 vs 6.3 mmol/L ± 1.6, P < .01; respectively); however, this did not hold true for Cho concentrations (1.7 mmol/L ± 0.5 vs 1.8 mmol/L ± 0.5). For individual differences between caudal and rostral measurements, only NAA in patients was different from that in control subjects (0.9 mmol/L ± 1.3 vs -0.1 mmol/L ± 0.5, P < .01), enabling prediction of schizophrenia with 68% sensitivity and 91% specificity, for a difference of more than 0.4.
Significant differences between caudal and rostral NAA concentration are found in ACC of patients with schizophrenia but not in ACC of healthy control subjects, indicating that neuronal density or integrity differences between ACC subregions may be characteristic of the disease. |
doi_str_mv | 10.1148/radiol.11110675 |
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This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty-two patients with schizophrenia (13 male, nine female; 39.4 years ± 10.6 [standard deviation]) and 11 age- and sex-matched control subjects (seven male, four female; 35.5 years ± 10.7) underwent magnetic resonance (MR) imaging and three-dimensional 3-T voxel proton MR spectroscopy to measure absolute rostral and caudal ACC N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) concentrations. Exact Mann-Whitney test was used to compare patient data with control data, paired-sample Wilcoxon signed rank test was used to compare subregions within groups, and receiver operating characteristic curve analysis was used to assess sensitivity and specificity in diagnosis of schizophrenia.
There were no significant metabolic differences between patients and control subjects or between ACC subregions in control subjects. In patients, rostral ACC NAA and Cr concentrations were significantly lower than those in caudal ACC (6.2 mM ± 1.3 vs 7.1 mM ± 1.3, P < .01; 5.7 mmol/L ± 1.4 vs 6.3 mmol/L ± 1.6, P < .01; respectively); however, this did not hold true for Cho concentrations (1.7 mmol/L ± 0.5 vs 1.8 mmol/L ± 0.5). For individual differences between caudal and rostral measurements, only NAA in patients was different from that in control subjects (0.9 mmol/L ± 1.3 vs -0.1 mmol/L ± 0.5, P < .01), enabling prediction of schizophrenia with 68% sensitivity and 91% specificity, for a difference of more than 0.4.
Significant differences between caudal and rostral NAA concentration are found in ACC of patients with schizophrenia but not in ACC of healthy control subjects, indicating that neuronal density or integrity differences between ACC subregions may be characteristic of the disease.</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.11110675</identifier><identifier>PMID: 21900615</identifier><identifier>CODEN: RADLAX</identifier><language>eng</language><publisher>Oak Brook, IL: Radiological Society of North America</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Case-Control Studies ; Choline ; Choline - metabolism ; Cortex (cingulate) ; Creatine ; Creatine - metabolism ; Data processing ; Female ; Gyrus Cinguli - metabolism ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic resonance imaging ; Magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Mental disorders ; N-Acetylaspartate ; Original Research ; Protons ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - metabolism ; Sensitivity and Specificity ; Standard deviation</subject><ispartof>Radiology, 2011-11, Vol.261 (2), p.542-550</ispartof><rights>2015 INIST-CNRS</rights><rights>RSNA, 2011</rights><rights>RSNA, 2011 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-af955db0cd2e525eed820690f69602a67834caa0500b9566045ced35abe1f9fc3</citedby><cites>FETCH-LOGICAL-c455t-af955db0cd2e525eed820690f69602a67834caa0500b9566045ced35abe1f9fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24612600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21900615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARDY, Caitlin J</creatorcontrib><creatorcontrib>TAL, Assaf</creatorcontrib><creatorcontrib>BABB, James S</creatorcontrib><creatorcontrib>PERRY, Nissa N</creatorcontrib><creatorcontrib>MESSINGER, Julie W</creatorcontrib><creatorcontrib>ANTONIUS, Daniel</creatorcontrib><creatorcontrib>MALASPINA, Dolores</creatorcontrib><creatorcontrib>GONEN, Oded</creatorcontrib><title>Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia</title><title>Radiology</title><addtitle>Radiology</addtitle><description>To test the hypothesis that anterior cingulate cortex (ACC) subregions in patients with schizophrenia are metabolically different from those in healthy control subjects.
This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty-two patients with schizophrenia (13 male, nine female; 39.4 years ± 10.6 [standard deviation]) and 11 age- and sex-matched control subjects (seven male, four female; 35.5 years ± 10.7) underwent magnetic resonance (MR) imaging and three-dimensional 3-T voxel proton MR spectroscopy to measure absolute rostral and caudal ACC N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) concentrations. Exact Mann-Whitney test was used to compare patient data with control data, paired-sample Wilcoxon signed rank test was used to compare subregions within groups, and receiver operating characteristic curve analysis was used to assess sensitivity and specificity in diagnosis of schizophrenia.
There were no significant metabolic differences between patients and control subjects or between ACC subregions in control subjects. In patients, rostral ACC NAA and Cr concentrations were significantly lower than those in caudal ACC (6.2 mM ± 1.3 vs 7.1 mM ± 1.3, P < .01; 5.7 mmol/L ± 1.4 vs 6.3 mmol/L ± 1.6, P < .01; respectively); however, this did not hold true for Cho concentrations (1.7 mmol/L ± 0.5 vs 1.8 mmol/L ± 0.5). For individual differences between caudal and rostral measurements, only NAA in patients was different from that in control subjects (0.9 mmol/L ± 1.3 vs -0.1 mmol/L ± 0.5, P < .01), enabling prediction of schizophrenia with 68% sensitivity and 91% specificity, for a difference of more than 0.4.
Significant differences between caudal and rostral NAA concentration are found in ACC of patients with schizophrenia but not in ACC of healthy control subjects, indicating that neuronal density or integrity differences between ACC subregions may be characteristic of the disease.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Choline</subject><subject>Choline - metabolism</subject><subject>Cortex (cingulate)</subject><subject>Creatine</subject><subject>Creatine - metabolism</subject><subject>Data processing</subject><subject>Female</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>N-Acetylaspartate</subject><subject>Original Research</subject><subject>Protons</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Sensitivity and Specificity</subject><subject>Standard deviation</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFv1DAQhS1ERZfCmRvyBcEl1JPYTnJBWi3QInVFRenZchynMfLawXYK5dK_Xq9228KF04zsz0_P8wahV0DeA9DmOMjeeJt7AMJr9gQtgJV1ARWwp2hBSFUVDYX2ED2P8QchQFlTP0OHJbSEcGALdLuebTLX_re2-Dz45B1ef8MXk1Yp-Kj8dIMvo-5x8vijicm4q9nEES9d0sH4gFfbEyuTxmudZOetUXjZOR820ppkdMTG4XOZO5ci_mXSiC_UaP74aQzaGfkCHQzSRv1yX4_Q5edP31enxdnXky-r5VmhKGOpkEPLWN8R1ZealUzrvikJb8nAW05KyeumokpKwgjpWsY5oUzpvmKy0zC0g6qO0Ied7jR3G92rbCdIK6ZgNjLcCC-N-PfGmVFc-WtRQduUUGeBt3uB4H_OOiaxMVFpa6XTfo5iO9CyoRQy-e6_JJC2opwCYRk93qEqDzsGPTwYAiK2AYtdwOI-4Pzi9d__eODvE83Amz0go5J2CNIpEx85yqHkeTHuAL7Dsvg</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>HARDY, Caitlin J</creator><creator>TAL, Assaf</creator><creator>BABB, James S</creator><creator>PERRY, Nissa N</creator><creator>MESSINGER, Julie W</creator><creator>ANTONIUS, Daniel</creator><creator>MALASPINA, Dolores</creator><creator>GONEN, Oded</creator><general>Radiological Society of North America</general><general>Radiological Society of North America, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia</title><author>HARDY, Caitlin J ; TAL, Assaf ; BABB, James S ; PERRY, Nissa N ; MESSINGER, Julie W ; ANTONIUS, Daniel ; MALASPINA, Dolores ; GONEN, Oded</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-af955db0cd2e525eed820690f69602a67834caa0500b9566045ced35abe1f9fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Choline</topic><topic>Choline - metabolism</topic><topic>Cortex (cingulate)</topic><topic>Creatine</topic><topic>Creatine - metabolism</topic><topic>Data processing</topic><topic>Female</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic resonance spectroscopy</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>N-Acetylaspartate</topic><topic>Original Research</topic><topic>Protons</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Sensitivity and Specificity</topic><topic>Standard deviation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARDY, Caitlin J</creatorcontrib><creatorcontrib>TAL, Assaf</creatorcontrib><creatorcontrib>BABB, James S</creatorcontrib><creatorcontrib>PERRY, Nissa N</creatorcontrib><creatorcontrib>MESSINGER, Julie W</creatorcontrib><creatorcontrib>ANTONIUS, Daniel</creatorcontrib><creatorcontrib>MALASPINA, Dolores</creatorcontrib><creatorcontrib>GONEN, Oded</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARDY, Caitlin J</au><au>TAL, Assaf</au><au>BABB, James S</au><au>PERRY, Nissa N</au><au>MESSINGER, Julie W</au><au>ANTONIUS, Daniel</au><au>MALASPINA, Dolores</au><au>GONEN, Oded</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>261</volume><issue>2</issue><spage>542</spage><epage>550</epage><pages>542-550</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><coden>RADLAX</coden><abstract>To test the hypothesis that anterior cingulate cortex (ACC) subregions in patients with schizophrenia are metabolically different from those in healthy control subjects.
This institutional review board-approved study was HIPAA compliant, and all participants provided written informed consent. Twenty-two patients with schizophrenia (13 male, nine female; 39.4 years ± 10.6 [standard deviation]) and 11 age- and sex-matched control subjects (seven male, four female; 35.5 years ± 10.7) underwent magnetic resonance (MR) imaging and three-dimensional 3-T voxel proton MR spectroscopy to measure absolute rostral and caudal ACC N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) concentrations. Exact Mann-Whitney test was used to compare patient data with control data, paired-sample Wilcoxon signed rank test was used to compare subregions within groups, and receiver operating characteristic curve analysis was used to assess sensitivity and specificity in diagnosis of schizophrenia.
There were no significant metabolic differences between patients and control subjects or between ACC subregions in control subjects. In patients, rostral ACC NAA and Cr concentrations were significantly lower than those in caudal ACC (6.2 mM ± 1.3 vs 7.1 mM ± 1.3, P < .01; 5.7 mmol/L ± 1.4 vs 6.3 mmol/L ± 1.6, P < .01; respectively); however, this did not hold true for Cho concentrations (1.7 mmol/L ± 0.5 vs 1.8 mmol/L ± 0.5). For individual differences between caudal and rostral measurements, only NAA in patients was different from that in control subjects (0.9 mmol/L ± 1.3 vs -0.1 mmol/L ± 0.5, P < .01), enabling prediction of schizophrenia with 68% sensitivity and 91% specificity, for a difference of more than 0.4.
Significant differences between caudal and rostral NAA concentration are found in ACC of patients with schizophrenia but not in ACC of healthy control subjects, indicating that neuronal density or integrity differences between ACC subregions may be characteristic of the disease.</abstract><cop>Oak Brook, IL</cop><pub>Radiological Society of North America</pub><pmid>21900615</pmid><doi>10.1148/radiol.11110675</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Adult and adolescent clinical studies Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Case-Control Studies Choline Choline - metabolism Cortex (cingulate) Creatine Creatine - metabolism Data processing Female Gyrus Cinguli - metabolism Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Magnetic resonance imaging Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Male Medical sciences Mental disorders N-Acetylaspartate Original Research Protons Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - metabolism Sensitivity and Specificity Standard deviation |
title | Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia |
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