Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cel...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2011-04, Vol.332 (6029), p.600-603 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 603 |
|---|---|
| container_issue | 6029 |
| container_start_page | 600 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 332 |
| creator | Qureshi, Omar S. Zheng, Yong Nakamura, Kyoko Attridge, Kesley Manzotti, Claire Schmidt, Emily M. Baker, Jennifer Jeffery, Louisa E. Kaur, Satdip Briggs, Zoe Hou, Tie Z. Futter, Clare E. Anderson, Graham Walker, Lucy S.K. Sansom, David M. |
| description | Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these costimulatory ligands are degraded inside CTLA-4—expressing cells, resulting in impaired costimulation via CD28. Acquisition of CD86 from antigen-presenting cells is stimulated by T cell receptor engagement and observed in vitro and in vivo. These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the cell-extrinsic depletion of ligands, accounting for many of the known features of the CD28—CTLA-4 system. |
| doi_str_mv | 10.1126/science.1202947 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3198051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>29784181</jstor_id><sourcerecordid>29784181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c615t-67086adfb336ec079bca1af8370c836f284988df0589b181ebf6a488d8bd66c53</originalsourceid><addsrcrecordid>eNqFkc9vFCEcxYnR2LV69qQhJk1P08LA8MODyXbdWpM1XtYzYRiwbGahwoyx_72MO221F08Q3oeX7_s-AF5jdIZxzc6z8TYYe4ZrVEvKn4AFRrKpZI3IU7BAiLBKIN4cgRc57xAqmiTPwVGNKacckwVQ26RDrtahi-Z2iNlnGB1cfRQI6tBNF_YeLuGX2Fsz9jrBCz0xLiY4XFu4sn1frX8NyYfsDbwcgxl8DH88tptlRV-CZ0732b6az2Pw7XK9XV1Vm6-fPq-Wm8ow3AwV40gw3bmWEGYN4rI1GmsnCEdGEOZqQaUQnUONkC0W2LaOaVpeRNsxZhpyDD4cfG_Gdm87Y8OQdK9ukt_rdKui9upfJfhr9T3-VARLgRpcDE5ngxR_jDYPau-zKfF0sHHMSpahKBZM_pcUjGJJaT2R7x6RuzimUPagBK9RQxDjBTo_QCbFnJN190NjpKaS1VyymksuP97-nfWev2u1ACczoLPRvSsVG58fOIobIvjEvTlwuzzE9KBLLkpUTH4D0uK4HQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>872053067</pqid></control><display><type>article</type><title>Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Qureshi, Omar S. ; Zheng, Yong ; Nakamura, Kyoko ; Attridge, Kesley ; Manzotti, Claire ; Schmidt, Emily M. ; Baker, Jennifer ; Jeffery, Louisa E. ; Kaur, Satdip ; Briggs, Zoe ; Hou, Tie Z. ; Futter, Clare E. ; Anderson, Graham ; Walker, Lucy S.K. ; Sansom, David M.</creator><creatorcontrib>Qureshi, Omar S. ; Zheng, Yong ; Nakamura, Kyoko ; Attridge, Kesley ; Manzotti, Claire ; Schmidt, Emily M. ; Baker, Jennifer ; Jeffery, Louisa E. ; Kaur, Satdip ; Briggs, Zoe ; Hou, Tie Z. ; Futter, Clare E. ; Anderson, Graham ; Walker, Lucy S.K. ; Sansom, David M.</creatorcontrib><description>Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these costimulatory ligands are degraded inside CTLA-4—expressing cells, resulting in impaired costimulation via CD28. Acquisition of CD86 from antigen-presenting cells is stimulated by T cell receptor engagement and observed in vitro and in vivo. These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the cell-extrinsic depletion of ligands, accounting for many of the known features of the CD28—CTLA-4 system.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1202947</identifier><identifier>PMID: 21474713</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Antibodies ; Antigen presenting cells ; Antigens ; Antigens, CD - immunology ; Antigens, CD - metabolism ; B7-1 Antigen - immunology ; B7-1 Antigen - metabolism ; B7-2 Antigen - immunology ; B7-2 Antigen - metabolism ; Biological and medical sciences ; Biomedical materials ; Blasts ; CD28 Antigens - immunology ; Cell lines ; Cell physiology ; CHO Cells ; Cricetinae ; Cricetulus ; CTLA-4 Antigen ; Degradation ; Dendritic Cells - immunology ; Depletion ; Endocytosis ; Fundamental and applied biological sciences. Psychology ; Humans ; In vitro testing ; Jurkat Cells ; Ligands ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Models, Biological ; Molecular and cellular biology ; Molecules ; Ova ; Ovalbumin - immunology ; Receptors ; Receptors, Antigen, T-Cell - immunology ; Recombinant Fusion Proteins - metabolism ; Surgical implants ; T lymphocytes ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6029), p.600-603</ispartof><rights>Copyright © 2011 The American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-67086adfb336ec079bca1af8370c836f284988df0589b181ebf6a488d8bd66c53</citedby><cites>FETCH-LOGICAL-c615t-67086adfb336ec079bca1af8370c836f284988df0589b181ebf6a488d8bd66c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29784181$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29784181$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24153873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21474713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qureshi, Omar S.</creatorcontrib><creatorcontrib>Zheng, Yong</creatorcontrib><creatorcontrib>Nakamura, Kyoko</creatorcontrib><creatorcontrib>Attridge, Kesley</creatorcontrib><creatorcontrib>Manzotti, Claire</creatorcontrib><creatorcontrib>Schmidt, Emily M.</creatorcontrib><creatorcontrib>Baker, Jennifer</creatorcontrib><creatorcontrib>Jeffery, Louisa E.</creatorcontrib><creatorcontrib>Kaur, Satdip</creatorcontrib><creatorcontrib>Briggs, Zoe</creatorcontrib><creatorcontrib>Hou, Tie Z.</creatorcontrib><creatorcontrib>Futter, Clare E.</creatorcontrib><creatorcontrib>Anderson, Graham</creatorcontrib><creatorcontrib>Walker, Lucy S.K.</creatorcontrib><creatorcontrib>Sansom, David M.</creatorcontrib><title>Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these costimulatory ligands are degraded inside CTLA-4—expressing cells, resulting in impaired costimulation via CD28. Acquisition of CD86 from antigen-presenting cells is stimulated by T cell receptor engagement and observed in vitro and in vivo. These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the cell-extrinsic depletion of ligands, accounting for many of the known features of the CD28—CTLA-4 system.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antigen presenting cells</subject><subject>Antigens</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - metabolism</subject><subject>B7-1 Antigen - immunology</subject><subject>B7-1 Antigen - metabolism</subject><subject>B7-2 Antigen - immunology</subject><subject>B7-2 Antigen - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Blasts</subject><subject>CD28 Antigens - immunology</subject><subject>Cell lines</subject><subject>Cell physiology</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>CTLA-4 Antigen</subject><subject>Degradation</subject><subject>Dendritic Cells - immunology</subject><subject>Depletion</subject><subject>Endocytosis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In vitro testing</subject><subject>Jurkat Cells</subject><subject>Ligands</subject><subject>Lymphocyte Activation</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Models, Biological</subject><subject>Molecular and cellular biology</subject><subject>Molecules</subject><subject>Ova</subject><subject>Ovalbumin - immunology</subject><subject>Receptors</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Surgical implants</subject><subject>T lymphocytes</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9vFCEcxYnR2LV69qQhJk1P08LA8MODyXbdWpM1XtYzYRiwbGahwoyx_72MO221F08Q3oeX7_s-AF5jdIZxzc6z8TYYe4ZrVEvKn4AFRrKpZI3IU7BAiLBKIN4cgRc57xAqmiTPwVGNKacckwVQ26RDrtahi-Z2iNlnGB1cfRQI6tBNF_YeLuGX2Fsz9jrBCz0xLiY4XFu4sn1frX8NyYfsDbwcgxl8DH88tptlRV-CZ0732b6az2Pw7XK9XV1Vm6-fPq-Wm8ow3AwV40gw3bmWEGYN4rI1GmsnCEdGEOZqQaUQnUONkC0W2LaOaVpeRNsxZhpyDD4cfG_Gdm87Y8OQdK9ukt_rdKui9upfJfhr9T3-VARLgRpcDE5ngxR_jDYPau-zKfF0sHHMSpahKBZM_pcUjGJJaT2R7x6RuzimUPagBK9RQxDjBTo_QCbFnJN190NjpKaS1VyymksuP97-nfWev2u1ACczoLPRvSsVG58fOIobIvjEvTlwuzzE9KBLLkpUTH4D0uK4HQ</recordid><startdate>20110429</startdate><enddate>20110429</enddate><creator>Qureshi, Omar S.</creator><creator>Zheng, Yong</creator><creator>Nakamura, Kyoko</creator><creator>Attridge, Kesley</creator><creator>Manzotti, Claire</creator><creator>Schmidt, Emily M.</creator><creator>Baker, Jennifer</creator><creator>Jeffery, Louisa E.</creator><creator>Kaur, Satdip</creator><creator>Briggs, Zoe</creator><creator>Hou, Tie Z.</creator><creator>Futter, Clare E.</creator><creator>Anderson, Graham</creator><creator>Walker, Lucy S.K.</creator><creator>Sansom, David M.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110429</creationdate><title>Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4</title><author>Qureshi, Omar S. ; Zheng, Yong ; Nakamura, Kyoko ; Attridge, Kesley ; Manzotti, Claire ; Schmidt, Emily M. ; Baker, Jennifer ; Jeffery, Louisa E. ; Kaur, Satdip ; Briggs, Zoe ; Hou, Tie Z. ; Futter, Clare E. ; Anderson, Graham ; Walker, Lucy S.K. ; Sansom, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-67086adfb336ec079bca1af8370c836f284988df0589b181ebf6a488d8bd66c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antigen presenting cells</topic><topic>Antigens</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD - metabolism</topic><topic>B7-1 Antigen - immunology</topic><topic>B7-1 Antigen - metabolism</topic><topic>B7-2 Antigen - immunology</topic><topic>B7-2 Antigen - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Blasts</topic><topic>CD28 Antigens - immunology</topic><topic>Cell lines</topic><topic>Cell physiology</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>CTLA-4 Antigen</topic><topic>Degradation</topic><topic>Dendritic Cells - immunology</topic><topic>Depletion</topic><topic>Endocytosis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>In vitro testing</topic><topic>Jurkat Cells</topic><topic>Ligands</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Models, Biological</topic><topic>Molecular and cellular biology</topic><topic>Molecules</topic><topic>Ova</topic><topic>Ovalbumin - immunology</topic><topic>Receptors</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Surgical implants</topic><topic>T lymphocytes</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qureshi, Omar S.</creatorcontrib><creatorcontrib>Zheng, Yong</creatorcontrib><creatorcontrib>Nakamura, Kyoko</creatorcontrib><creatorcontrib>Attridge, Kesley</creatorcontrib><creatorcontrib>Manzotti, Claire</creatorcontrib><creatorcontrib>Schmidt, Emily M.</creatorcontrib><creatorcontrib>Baker, Jennifer</creatorcontrib><creatorcontrib>Jeffery, Louisa E.</creatorcontrib><creatorcontrib>Kaur, Satdip</creatorcontrib><creatorcontrib>Briggs, Zoe</creatorcontrib><creatorcontrib>Hou, Tie Z.</creatorcontrib><creatorcontrib>Futter, Clare E.</creatorcontrib><creatorcontrib>Anderson, Graham</creatorcontrib><creatorcontrib>Walker, Lucy S.K.</creatorcontrib><creatorcontrib>Sansom, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qureshi, Omar S.</au><au>Zheng, Yong</au><au>Nakamura, Kyoko</au><au>Attridge, Kesley</au><au>Manzotti, Claire</au><au>Schmidt, Emily M.</au><au>Baker, Jennifer</au><au>Jeffery, Louisa E.</au><au>Kaur, Satdip</au><au>Briggs, Zoe</au><au>Hou, Tie Z.</au><au>Futter, Clare E.</au><au>Anderson, Graham</au><au>Walker, Lucy S.K.</au><au>Sansom, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2011-04-29</date><risdate>2011</risdate><volume>332</volume><issue>6029</issue><spage>600</spage><epage>603</epage><pages>600-603</pages><issn>0036-8075</issn><issn>1095-9203</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Cytotoxic T lymphocyte antigen 4 (CTLA-4) is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here, we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocytosis. After removal, these costimulatory ligands are degraded inside CTLA-4—expressing cells, resulting in impaired costimulation via CD28. Acquisition of CD86 from antigen-presenting cells is stimulated by T cell receptor engagement and observed in vitro and in vivo. These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector molecule to inhibit CD28 costimulation by the cell-extrinsic depletion of ligands, accounting for many of the known features of the CD28—CTLA-4 system.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>21474713</pmid><doi>10.1126/science.1202947</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6029), p.600-603 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3198051 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Antibodies Antigen presenting cells Antigens Antigens, CD - immunology Antigens, CD - metabolism B7-1 Antigen - immunology B7-1 Antigen - metabolism B7-2 Antigen - immunology B7-2 Antigen - metabolism Biological and medical sciences Biomedical materials Blasts CD28 Antigens - immunology Cell lines Cell physiology CHO Cells Cricetinae Cricetulus CTLA-4 Antigen Degradation Dendritic Cells - immunology Depletion Endocytosis Fundamental and applied biological sciences. Psychology Humans In vitro testing Jurkat Cells Ligands Lymphocyte Activation Mice Mice, Transgenic Models, Biological Molecular and cellular biology Molecules Ova Ovalbumin - immunology Receptors Receptors, Antigen, T-Cell - immunology Recombinant Fusion Proteins - metabolism Surgical implants T lymphocytes T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism |
| title | Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T23%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trans-Endocytosis%20of%20CD80%20and%20CD86:%20A%20Molecular%20Basis%20for%20the%20Cell-Extrinsic%20Function%20of%20CTLA-4&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Qureshi,%20Omar%20S.&rft.date=2011-04-29&rft.volume=332&rft.issue=6029&rft.spage=600&rft.epage=603&rft.pages=600-603&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1202947&rft_dat=%3Cjstor_pubme%3E29784181%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=872053067&rft_id=info:pmid/21474713&rft_jstor_id=29784181&rfr_iscdi=true |