Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3

AIM： To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 （STAT3） activity in hepatocellular carcinoma （HCC）.METHODS： Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation wer...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2011-09, Vol.17 (34), p.3922-3932
Hauptverfasser:	Gu, Fang-Ming, Li, Quan-Lin, Gao, Qiang, Jiang, Jia-Hao, Huang, Xiao-Yong, Pan, Jin-Feng, Fan, Jia, Zhou, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzenesulfonates - pharmacology Benzenesulfonates - therapeutic use Brief Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Enzyme Inhibitors - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Humans Janus Kinase 2 - metabolism Janus激酶 Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mitogen-Activated Protein Kinase Kinases - metabolism Neoplasm Metastasis Niacinamide - analogs & derivatives Phenylurea Compounds Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Pyridines - therapeutic use Rats Signal Transduction - drug effects STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism 信号转导去磷酸化磷脂酰肌醇-3 细胞外信号调节激酶细胞生长肝癌
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