Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects

In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimag...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2008-11, Vol.43 (3), p.458-469
Hauptverfasser:	Hua, Xue, Leow, Alex D., Parikshak, Neelroop, Lee, Suh, Chiang, Ming-Chang, Toga, Arthur W., Jack, Clifford R., Weiner, Michael W., Thompson, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Apolipoprotein E4 Apolipoprotein E4 - genetics Atrophy biomarkers Brain - pathology Brain mapping Brain Mapping - methods Cognitive ability Compression Dementia Dementia disorders Disease Progression Gene mapping Geriatrics Hippocampus Humans Image processing Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging Memory Morphometry Neurodegenerative diseases Neuroimaging Neuropsychological Tests Pharmaceutical industry Studies Temporal lobe
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