WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication

The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health risks for cancer and mitochondrial disease. Thus, agents that mitigate t...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2009-07, Vol.50 (6), p.460-472
Hauptverfasser:	Walker, Dale M, Kajon, Adriana E, Torres, Salina M, Carter, Meghan M, McCash, Consuelo L, Swenberg, James A, Upton, Patricia B, Hardy, Andrew W, Olivero, Ofelia A, Shearer, Gene M, Poirier, Miriam C, Walker, Vernon E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - drug effects Adenoviridae - physiology Adenovirus amifostine antimutagenesis antiviral Cell Line Cytoplasm - drug effects Cytoplasm - metabolism cytoprotection Didanosine - analogs & derivatives Didanosine - toxicity Dideoxynucleotides - toxicity Dose-Response Relationship, Drug HIV Core Protein p24 - metabolism HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus 1 Humans Hypoxanthine Phosphoribosyltransferase - genetics Influenza A virus - drug effects Influenza A virus - physiology Influenza B virus - drug effects Influenza B virus - physiology Intracellular Space - drug effects Intracellular Space - metabolism Lymphocytes - drug effects Lymphocytes - virology Mercaptoethylamines - pharmacology Mutagenesis - drug effects Mutation - genetics Phytohemagglutinins - pharmacology Serotyping Time Factors Virus Replication - drug effects WR1065 Zidovudine - analogs & derivatives Zidovudine - toxicity
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