TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3

Transforming growth factor β-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essential role in the transforming growth factor β-signaling pathway, but recent evidence has emerged implicating TAK1 in the interleukin (IL)-1 and tumor necrosis factor (TNF) p...

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Veröffentlicht in:	The Journal of biological chemistry 2007-02, Vol.282 (6), p.3918-3928
Hauptverfasser:	Besse, Arnaud, Lamothe, Betty, Campos, Alejandro D., Webster, William K., Maddineni, Upendra, Lin, Su-Chang, Wu, Hao, Darnay, Bryant G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Amino Acid Sequence Animals Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Humans Interleukin-1 - physiology Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - physiology L Cells MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Kinase Kinases - physiology Mice Molecular Sequence Data Osteoclasts - cytology Osteoclasts - physiology Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - physiology Protein Binding - genetics Protein Binding - physiology Protein Structure, Tertiary - genetics Protein Structure, Tertiary - physiology RANK Ligand - physiology Sequence Deletion Signal Transduction - genetics Signal Transduction - physiology Tumor Necrosis Factor-alpha - physiology
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