An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR

Mammalian target of rapamycin (mTOR), a large multidomain protein kinase, regulates cell growth and metabolism in response to environmental signals. The FKBP rapamycin-binding (FRB) domain of mTOR is a validated therapeutic target for the development of immunosuppressant and anticancer drugs but is...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2011-11, Vol.24 (11), p.811-817
Hauptverfasser:	Sekiguchi, Mitsuhiro, Kobashigawa, Yoshihiro, Kawasaki, Masashi, Yokochi, Masashi, Kiso, Tetsuo, Suzumura, Ken-ichi, Mori, Keitaro, Teramura, Toshio, Inagaki, Fuyuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning - methods Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Escherichia coli Humans Ligands Magnetic Resonance Spectroscopy - methods Original Protein Binding - drug effects Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Tacrolimus Binding Protein 1A - antagonists & inhibitors Tacrolimus Binding Protein 1A - chemistry Tacrolimus Binding Protein 1A - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - chemistry TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
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