Charcot-Marie-Tooth-related Gene GDAP1 Complements Cell Cycle Delay at G2/M Phase in Saccharomyces cerevisiae fis1 Gene-defective Cells

Mutations in the GDAP1 gene are responsible of the Charcot-Marie-Tooth CMT4A, ARCMT2K, and CMT2K variants. GDAP1 is a mitochondrial outer membrane protein that has been related to the fission pathway of the mitochondrial network dynamics. As mitochondrial dynamics is a conserved process, we reasoned...

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Veröffentlicht in:	The Journal of biological chemistry 2011-10, Vol.286 (42), p.36777-36786
Hauptverfasser:	Estela, Anna, Pla-Martín, David, Sánchez-Piris, Maribel, Sesaki, Hiromi, Palau, Francesc
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Cell Division Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease - genetics Charcot-Marie-Tooth Disease - metabolism Cytoskeleton fis1 G2 Phase GDAP1 Genetic Complementation Test HeLa Cells Humans Microtubules - genetics Microtubules - metabolism Mitochondria - genetics Mitochondria - metabolism Mitochondrial Dynamics Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mitotic Spindle Molecular Bases of Disease Mutation, Missense Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oxidative Stress Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Tubulin - genetics Tubulin - metabolism Yeast
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