Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases
This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spiro...
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| Veröffentlicht in: | Canadian veterinary journal 2011-11, Vol.52 (11), p.1219-1225 |
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| creator | de Madron, Eric King, Jonathan N Strehlau, Günther White, Regina Valle |
| description | This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spironolactone, and amlodipine. Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate. |
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Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate.</description><identifier>ISSN: 0008-5286</identifier><identifier>PMID: 22547843</identifier><language>eng</language><publisher>Canada: Canadian Veterinary Medical Association</publisher><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; Benzazepines - therapeutic use ; Cardiotonic Agents - therapeutic use ; Death, Sudden, Cardiac - prevention & control ; Death, Sudden, Cardiac - veterinary ; Dog Diseases - diagnostic imaging ; Dog Diseases - drug therapy ; Dog Diseases - mortality ; Dogs ; Drug Therapy, Combination - veterinary ; Enalapril - therapeutic use ; Female ; Furosemide - therapeutic use ; Heart Failure - drug therapy ; Heart Failure - etiology ; Heart Failure - mortality ; Heart Failure - veterinary ; Male ; Mitral Valve Insufficiency - complications ; Mitral Valve Insufficiency - drug therapy ; Mitral Valve Insufficiency - mortality ; Mitral Valve Insufficiency - veterinary ; Pyridazines - therapeutic use ; Retrospective Studies ; Scientific ; Ultrasonography</subject><ispartof>Canadian veterinary journal, 2011-11, Vol.52 (11), p.1219-1225</ispartof><rights>Copyright and/or publishing rights held by the Canadian Veterinary Medical Association 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196016/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196016/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22547843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Madron, Eric</creatorcontrib><creatorcontrib>King, Jonathan N</creatorcontrib><creatorcontrib>Strehlau, Günther</creatorcontrib><creatorcontrib>White, Regina Valle</creatorcontrib><title>Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases</title><title>Canadian veterinary journal</title><addtitle>Can Vet J</addtitle><description>This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spironolactone, and amlodipine. Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate.</description><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Benzazepines - therapeutic use</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Death, Sudden, Cardiac - veterinary</subject><subject>Dog Diseases - diagnostic imaging</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - mortality</subject><subject>Dogs</subject><subject>Drug Therapy, Combination - veterinary</subject><subject>Enalapril - therapeutic use</subject><subject>Female</subject><subject>Furosemide - therapeutic use</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - veterinary</subject><subject>Male</subject><subject>Mitral Valve Insufficiency - complications</subject><subject>Mitral Valve Insufficiency - drug therapy</subject><subject>Mitral Valve Insufficiency - mortality</subject><subject>Mitral Valve Insufficiency - veterinary</subject><subject>Pyridazines - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Scientific</subject><subject>Ultrasonography</subject><issn>0008-5286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkclKxEAQhnNQnHF5Bemjl0B39ngQZHCDAQ_qOdR0VyctSTr2EplH8i1tx1H0VBT_z_fXchAtKaVVnCdVsYiOrX2lNKlZQY-iRZLkWVll6TL6ePJmVjP0BEZBkHeagxFKtwamTnEiwAFRIxG6teRduY5wPbZonZqRdAjGEQmq9wYJB29RkM2WDMqZQAzUYBLKIljc8Z1BcHuP752a-qAb39pLAsSgM9pOyHds67zYEi1JwgLZoj2NDiX0Fs_29SR6ub15Xt3H68e7h9X1Op6SonAxL0We8pRVpRSyZnWR5CXkWeg3TEAla4qS8bqWdU0LiQwrYDlkeUYRWZWy9CS6-uZOfjOg4Dh-LdNMRg1gto0G1fxXRtU1rZ6bNIRRVgTAxR5g9JsPp2oGZTn2PYyovW0YZbRIw0hlsJ7_zfoN-flP-gkYho_6</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>de Madron, Eric</creator><creator>King, Jonathan N</creator><creator>Strehlau, Günther</creator><creator>White, Regina Valle</creator><general>Canadian Veterinary Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201111</creationdate><title>Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases</title><author>de Madron, Eric ; King, Jonathan N ; Strehlau, Günther ; White, Regina Valle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-c7d53c3187fdf9196257a54187b1da8f90ef1c99f9906fe1e8a15a4540ee18313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Benzazepines - therapeutic use</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>Death, Sudden, Cardiac - veterinary</topic><topic>Dog Diseases - diagnostic imaging</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - mortality</topic><topic>Dogs</topic><topic>Drug Therapy, Combination - veterinary</topic><topic>Enalapril - therapeutic use</topic><topic>Female</topic><topic>Furosemide - therapeutic use</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - veterinary</topic><topic>Male</topic><topic>Mitral Valve Insufficiency - complications</topic><topic>Mitral Valve Insufficiency - drug therapy</topic><topic>Mitral Valve Insufficiency - mortality</topic><topic>Mitral Valve Insufficiency - veterinary</topic><topic>Pyridazines - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Scientific</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Madron, Eric</creatorcontrib><creatorcontrib>King, Jonathan N</creatorcontrib><creatorcontrib>Strehlau, Günther</creatorcontrib><creatorcontrib>White, Regina Valle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Madron, Eric</au><au>King, Jonathan N</au><au>Strehlau, Günther</au><au>White, Regina Valle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases</atitle><jtitle>Canadian veterinary journal</jtitle><addtitle>Can Vet J</addtitle><date>2011-11</date><risdate>2011</risdate><volume>52</volume><issue>11</issue><spage>1219</spage><epage>1225</epage><pages>1219-1225</pages><issn>0008-5286</issn><abstract>This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spironolactone, and amlodipine. Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate.</abstract><cop>Canada</cop><pub>Canadian Veterinary Medical Association</pub><pmid>22547843</pmid><tpages>7</tpages></addata></record> |
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| subjects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Benzazepines - therapeutic use Cardiotonic Agents - therapeutic use Death, Sudden, Cardiac - prevention & control Death, Sudden, Cardiac - veterinary Dog Diseases - diagnostic imaging Dog Diseases - drug therapy Dog Diseases - mortality Dogs Drug Therapy, Combination - veterinary Enalapril - therapeutic use Female Furosemide - therapeutic use Heart Failure - drug therapy Heart Failure - etiology Heart Failure - mortality Heart Failure - veterinary Male Mitral Valve Insufficiency - complications Mitral Valve Insufficiency - drug therapy Mitral Valve Insufficiency - mortality Mitral Valve Insufficiency - veterinary Pyridazines - therapeutic use Retrospective Studies Scientific Ultrasonography |
| title | Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases |
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