Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis

Chitin is an abundant polysaccharide found in fungal cell walls, crustacean shells, and insect exoskeletons. The immunological properties of both chitin and its deacetylated derivative chitosan are of relevance because of frequent natural exposure and their use in medical applications. Depending on...

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Veröffentlicht in:	The Journal of biological chemistry 2011-10, Vol.286 (41), p.35447-35455
Hauptverfasser:	Bueter, Chelsea L., Lee, Chrono K., Rathinam, Vijay A.K., Healy, Gloria J., Taron, Christopher H., Specht, Charles A., Levitz, Stuart M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Chemistry Carrier Proteins - genetics Carrier Proteins - immunology Carrier Proteins - metabolism Cell Line Chitin Chitin - chemistry Chitin - immunology Chitin - isolation & purification Chitin - pharmacology Chitosan Chitosan - chemistry Chitosan - immunology Chitosan - isolation & purification Chitosan - pharmacology Cytochalasin D - pharmacology Cytokine Induction Fungi Hemostatics - chemistry Hemostatics - isolation & purification Hemostatics - pharmacology Immunology Inflammasomes - genetics Inflammasomes - immunology Inflammasomes - metabolism Interleukin Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-1beta - metabolism Macrophages Macrophages - immunology Macrophages - metabolism Mice Mice, Knockout NLR Family, Pyrin Domain-Containing 3 Protein Nucleic Acid Synthesis Inhibitors - pharmacology Phagocytosis Phagocytosis - drug effects Phagocytosis - immunology Structure-Activity Relationship
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