Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb10 as an mTORC1 Substrate that Negatively Regulates Insulin Signaling

The evolutionarily conserved Ser-Thr kinase mTOR plays a critical role in regulating many pathophysiological processes. Functional characterization of the mTOR signaling pathways, however, has been hampered by the paucity of known substrates. We used large-scale quantitative phospho-proteomics exper...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2011-06, Vol.332 (6035), p.1322-1326
Hauptverfasser:	Yu, Yonghao, Yoon, Sang-Oh, Poulogiannis, George, Yang, Qian, Ma, Xiaoju Max, Villén, Judit, Kubica, Neil, Hoffman, Gregory R., Cantley, Lewis C., Gygi, Steven P., Blenis, John
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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