APC +/- alters colonic fibroblast proteome in FAP

Here we compared the proteomes of primary fibroblast cultures derived from morphologically normal colonic mucosa of familial adenomatous polyposis (FAP) patients with those obtained from unaffected controls. The expression signature of about 19% of total fibroblast proteins separates FAP mutation ca...

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Veröffentlicht in:	Oncotarget 2011-03, Vol.2 (3), p.197-208
Hauptverfasser:	Patel, Bhavinkumar B, Li, Xin-Ming, Dixon, Maketa P, Blagoi, Elena L, Nicolas, Emmanuelle, Seeholzer, Steven H, Cheng, David, He, Yin A, Coudry, Renata A, Howard, Sharon D, Riddle, Dawn M, Cooper, Harry C, Boman, Bruce M, Conrad, Peggy, Crowell, James A, Bellacosa, Alfonso, Knudson, Alfred, Yeung, Anthony T, Kopelovich, Levy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Adenomatous Polyposis Coli - pathology Adult Aged Case-Control Studies Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation, Neoplastic Genes, APC Heterozygote Humans Intracellular Signaling Peptides and Proteins - genetics Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Oxidative Stress - genetics Protein Deglycase DJ-1 Proteome - biosynthesis Proteome - genetics Research Papers Transcription Factors - biosynthesis Transcription Factors - genetics Young Adult
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