p53 Transformation-Related Protein: Detection of an Associated Phosphotransferase Activity

Malignant cells of the mouse transformed by a variety of different agents have been found to express high levels of a 53,000 Mrphosphoprotein (designated p53). Little or no p53 can be detected in normal mouse cells. The nucleus appears to be the predominant site of p53 localization in transformed ce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1981-05, Vol.78 (5), p.2932-2936
Hauptverfasser:	Jay, Gilbert, Khoury, George, DeLeo, Albert B., Dippold, Wolfgang G., Old, Lloyd J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Animals Antibodies Antibodies, Monoclonal Antigen antibody complex B lymphocytes Cations, Divalent Cell Line Cell lines Cell Transformation, Viral Cellular immunity Clone Cells Immune Sera Kinetics Mice Monoclonal antibodies Phosphoproteins - analysis Phosphorylation Phosphotransferases - metabolism Protein Kinases - metabolism Sarcoma Simian virus 40 - genetics Tumor Suppressor Protein p53 Tumors Viral tumor antigens
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