Role of increased CD8/CD28null T cells and alternative co‐stimulatory molecules in chronic obstructive pulmonary disease

Summary Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease; it is a leading cause of death and existing treatments have no proven disease‐modifying effect. The mechanisms underlying this resistance are largely unknown, but suggest the presence of some self‐maintainin...

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Veröffentlicht in:	Clinical and experimental immunology 2011-10, Vol.166 (1), p.94-102
Hauptverfasser:	Hodge, G., Mukaro, V., Reynolds, P. N., Hodge, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animal models B7-1 antigen Biological and medical sciences Blood CD28 antigen CD4 antigen CD8 antigen CD8/CD28null T cells Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Cigarette smoke Cigarette smoking COPD co‐stimulatory molecules CTLA-4 protein Cytokines endopeptidase Fundamental and applied biological sciences. Psychology granzyme granzyme B Immune system Inflammation Inflammatory diseases Interferon Lung diseases Lymphocytes Lymphocytes T Medical sciences OX40L protein Perforin Pneumology Respiratory tract Rodents Serine proteinase smoking mouse model Tobacco, tobacco smoking Toxicology Translational Studies Tumor necrosis factor
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