Balancing act: deubiquitinating enzymes in the nervous system
Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2011-07, Vol.34 (7), p.370-382 |
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| creator | Todi, Sokol V Paulson, Henry L |
| description | Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity. The significance of DUBs to the nervous system is underscored by links to various neurological diseases. Owing to cell type or substrate specificity, certain DUBs might also represent therapeutic targets for neurodegeneration. Here, we review recent findings that have shaped our current understanding of emerging functions for DUBs in the nervous system. |
| doi_str_mv | 10.1016/j.tins.2011.05.004 |
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| identifier | ISSN: 0166-2236 |
| ispartof | Trends in neurosciences (Regular ed.), 2011-07, Vol.34 (7), p.370-382 |
| issn | 0166-2236 1878-108X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cells Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Human viral diseases Humans Infectious diseases Medical sciences Nervous system Nervous System - enzymology Neurological disorders Neurology Neurons - enzymology Proteins Ubiquitin-Specific Proteases - physiology Ubiquitination - physiology Vertebrates: nervous system and sense organs Viral diseases Viral diseases of the nervous system |
| title | Balancing act: deubiquitinating enzymes in the nervous system |
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