Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis
Introduction: High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultr...
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| Veröffentlicht in: | Muscle & nerve 2011-09, Vol.44 (3), p.346-351 |
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| creator | Cartwright, Michael S. Walker, Francis O. Griffin, Leah P. Caress, James B. |
| description | Introduction:
High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultrasound to investigate nerve cross‐sectional area and muscle thickness in ALS.
Methods:
Twenty individuals with ALS and 20 matched controls underwent neuromuscular ultrasound to measure the cross‐sectional area of their median and sural nerves and the thickness of their biceps/brachialis muscle complex.
Results:
The cross‐sectional area of the median nerve in the mid‐arm was smaller in the ALS group than in controls (10.5 mm2 vs. 12.7 mm2, P = 0.0023), but no difference was seen in the sural nerve (4.5 mm2 vs. 5.0 mm2, P = 0.1927). The ALS group also had thinner biceps/brachialis than controls (2.1 cm vs. 2.9 cm, P = 0.0007).
Conclusions:
Neuromuscular ultrasound demonstrates nerve and muscle atrophy in ALS and should be further explored as a disease biomarker. Muscle Nerve 44: 346–351, 2011 |
| doi_str_mv | 10.1002/mus.22035 |
| format | Article |
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High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultrasound to investigate nerve cross‐sectional area and muscle thickness in ALS.
Methods:
Twenty individuals with ALS and 20 matched controls underwent neuromuscular ultrasound to measure the cross‐sectional area of their median and sural nerves and the thickness of their biceps/brachialis muscle complex.
Results:
The cross‐sectional area of the median nerve in the mid‐arm was smaller in the ALS group than in controls (10.5 mm2 vs. 12.7 mm2, P = 0.0023), but no difference was seen in the sural nerve (4.5 mm2 vs. 5.0 mm2, P = 0.1927). The ALS group also had thinner biceps/brachialis than controls (2.1 cm vs. 2.9 cm, P = 0.0007).
Conclusions:
Neuromuscular ultrasound demonstrates nerve and muscle atrophy in ALS and should be further explored as a disease biomarker. Muscle Nerve 44: 346–351, 2011</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.22035</identifier><identifier>PMID: 21815172</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - diagnostic imaging ; Biological and medical sciences ; Case-Control Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diseases of striated muscles. Neuromuscular diseases ; Female ; Humans ; Male ; median nerve ; Median Nerve - diagnostic imaging ; Medical sciences ; Middle Aged ; muscle ; Muscle, Skeletal - diagnostic imaging ; Muscular Atrophy - diagnostic imaging ; Neurology ; Peripheral Nerves - diagnostic imaging ; sural nerve ; Sural Nerve - diagnostic imaging ; Ultrasonography ; ultrasound</subject><ispartof>Muscle & nerve, 2011-09, Vol.44 (3), p.346-351</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5485-a152f192916ddfa4c97c66dfeb5d8e95d96f36b42146c18fa48a12234bfb2043</citedby><cites>FETCH-LOGICAL-c5485-a152f192916ddfa4c97c66dfeb5d8e95d96f36b42146c18fa48a12234bfb2043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.22035$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.22035$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24492300$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21815172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cartwright, Michael S.</creatorcontrib><creatorcontrib>Walker, Francis O.</creatorcontrib><creatorcontrib>Griffin, Leah P.</creatorcontrib><creatorcontrib>Caress, James B.</creatorcontrib><title>Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction:
High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultrasound to investigate nerve cross‐sectional area and muscle thickness in ALS.
Methods:
Twenty individuals with ALS and 20 matched controls underwent neuromuscular ultrasound to measure the cross‐sectional area of their median and sural nerves and the thickness of their biceps/brachialis muscle complex.
Results:
The cross‐sectional area of the median nerve in the mid‐arm was smaller in the ALS group than in controls (10.5 mm2 vs. 12.7 mm2, P = 0.0023), but no difference was seen in the sural nerve (4.5 mm2 vs. 5.0 mm2, P = 0.1927). The ALS group also had thinner biceps/brachialis than controls (2.1 cm vs. 2.9 cm, P = 0.0007).
Conclusions:
Neuromuscular ultrasound demonstrates nerve and muscle atrophy in ALS and should be further explored as a disease biomarker. Muscle Nerve 44: 346–351, 2011</description><subject>Adult</subject><subject>Aged</subject><subject>amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>median nerve</subject><subject>Median Nerve - diagnostic imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>muscle</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscular Atrophy - diagnostic imaging</subject><subject>Neurology</subject><subject>Peripheral Nerves - diagnostic imaging</subject><subject>sural nerve</subject><subject>Sural Nerve - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>ultrasound</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlO3DAAhi3UCobl0BeocqkQh4D32JdKiGVaRCliEb1ZjuN0DE4y2Akwb18PM0zpoSdL9vcv_gH4hOA-ghAfNEPcxxgStgZGCMoip0yKD2AEERU5J_LXBtiM8R5CiAQv1sEGRgIxVOARGF_a4KYTG7TPWhuebKbbKkuGxtts8H3QsRvSjWsz3cy6PnTTiTOZ1_2rZI6FLrq4DT7W2ke7szy3wM3pyc3Rt_z85_j70eF5bhgVLNeI4RpJLBGvqlpTIwvDeVXbklXCSlZJXhNeUowoN0gkQmiEMaFlXWJIyRb4urCdDmVjK2Pb1NCraXCNDjPVaaf-fWndRP3unhRBkjABk8Hu0iB0j4ONvWpcNNZ73dpuiEpIwdJKhCRyb0Ga9MEYbL1KQVDNZ1dpJfU6e2I_v6-1It92TsCXJaCj0b4OujUu_uUolZjAeb2DBffsvJ39P1H9uL1-i84XChd7-7JS6PCgeEEKpu4uxury6uzsuLi7UMfkD4IXqpg</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Cartwright, Michael S.</creator><creator>Walker, Francis O.</creator><creator>Griffin, Leah P.</creator><creator>Caress, James B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201109</creationdate><title>Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis</title><author>Cartwright, Michael S. ; Walker, Francis O. ; Griffin, Leah P. ; Caress, James B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5485-a152f192916ddfa4c97c66dfeb5d8e95d96f36b42146c18fa48a12234bfb2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>median nerve</topic><topic>Median Nerve - diagnostic imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>muscle</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscular Atrophy - diagnostic imaging</topic><topic>Neurology</topic><topic>Peripheral Nerves - diagnostic imaging</topic><topic>sural nerve</topic><topic>Sural Nerve - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cartwright, Michael S.</creatorcontrib><creatorcontrib>Walker, Francis O.</creatorcontrib><creatorcontrib>Griffin, Leah P.</creatorcontrib><creatorcontrib>Caress, James B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartwright, Michael S.</au><au>Walker, Francis O.</au><au>Griffin, Leah P.</au><au>Caress, James B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2011-09</date><risdate>2011</risdate><volume>44</volume><issue>3</issue><spage>346</spage><epage>351</epage><pages>346-351</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Introduction:
High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultrasound to investigate nerve cross‐sectional area and muscle thickness in ALS.
Methods:
Twenty individuals with ALS and 20 matched controls underwent neuromuscular ultrasound to measure the cross‐sectional area of their median and sural nerves and the thickness of their biceps/brachialis muscle complex.
Results:
The cross‐sectional area of the median nerve in the mid‐arm was smaller in the ALS group than in controls (10.5 mm2 vs. 12.7 mm2, P = 0.0023), but no difference was seen in the sural nerve (4.5 mm2 vs. 5.0 mm2, P = 0.1927). The ALS group also had thinner biceps/brachialis than controls (2.1 cm vs. 2.9 cm, P = 0.0007).
Conclusions:
Neuromuscular ultrasound demonstrates nerve and muscle atrophy in ALS and should be further explored as a disease biomarker. Muscle Nerve 44: 346–351, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21815172</pmid><doi>10.1002/mus.22035</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnostic imaging Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diseases of striated muscles. Neuromuscular diseases Female Humans Male median nerve Median Nerve - diagnostic imaging Medical sciences Middle Aged muscle Muscle, Skeletal - diagnostic imaging Muscular Atrophy - diagnostic imaging Neurology Peripheral Nerves - diagnostic imaging sural nerve Sural Nerve - diagnostic imaging Ultrasonography ultrasound |
| title | Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis |
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