Structural basis of pre-mRNA recognition by the human cleavage factor Im complex

The cleavage factor Im （CF Im）, consists of a 25 kDa subunit （CF Im25） and one of three larger subunits （CF Im59, CF Im68, CF Im72）, and is an essential protein complex for pre-mRNA 3＇-end cleavage and polyadenylation. It recognizes the upstream sequence of the poly（A） site in a sequence-dependent m...

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