Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer
Background The prognosis for patients with esophageal cancer is poor, even among those who undergo potentially curative esophagectomy. The neutrophil:lymphocyte ratio (NLR) is hypothesized to reflect the systemic inflammatory response created by a tumor and is possibly predictive of tumor aggressive...
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| Veröffentlicht in: | Annals of surgical oncology 2011-11, Vol.18 (12), p.3362-3369 |
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| creator | Sharaiha, Reem Z. Halazun, Karim J. Mirza, Farooq Port, Jeffrey L. Lee, Paul C. Neugut, Alfred I. Altorki, Nasser K. Abrams, Julian A. |
| description | Background
The prognosis for patients with esophageal cancer is poor, even among those who undergo potentially curative esophagectomy. The neutrophil:lymphocyte ratio (NLR) is hypothesized to reflect the systemic inflammatory response created by a tumor and is possibly predictive of tumor aggressiveness and propensity for metastasis.
Methods
We performed a single-center retrospective analysis of esophageal cancer patients who underwent attempted curative esophagectomy at Weill Cornell Medical Center between 1996 and 2009. We collected data on patient demographics, clinical characteristics, and receipt of neoadjuvant treatment. Preoperative blood tests were used to calculate NLR. Elevated NLR was defined a priori as ≥5.0. Logistic regression modeling was performed to analyze characteristics associated with elevated NLR. We conducted Kaplan-Meier analyses and Cox regression modeling to determine estimates and predictors of disease-free and overall survival.
Results
We identified a total of 295 patients who underwent esophagectomy. The median duration of follow-up was 31 months (interquartile range [IQR] 13–61). There were 56 patients (18.9%) who had elevated NLR preoperatively. Receipt of neoadjuvant therapy was independently associated with high NLR (odds ratio [OR] 2.14, 95% confidence interval [95% CI] 1.02–4.51). In multivariable analyses, elevated NLR was associated with significantly worse disease-free (hazard ratio [HR] 2.26, 95% CI 1.43–3.55) and overall survival (HR 2.31, 95% CI 1.53–3.50).
Conclusions
Preoperative NLR is a potential prognostic marker for recurrence and death after esophagectomy. It is unclear whether NLR reflects the degree of inflammatory response to the primary tumor or other patient-specific or tumor characteristics that predispose to recurrence. Further investigation is warranted to clarify the mechanisms explaining the observed associations between elevated NLR and poor outcomes in esophageal cancer. |
| doi_str_mv | 10.1245/s10434-011-1754-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2483652681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c567t-6e789518f09f0cc3b7e76e87ed28bd2763c996526c44da3b94ffcf42d70c45b33</originalsourceid><addsrcrecordid>eNp9kkuLFDEUhQtRnHH0B7iR4EY3pXk_XAjStg9odBBdh1TqVncN1ZWaJNXQ_94UPc6ooKuEe757bh6nqp4S_IpQLl4ngjnjNSakJkrwWt-rzokoFS41uV_2WOraUCnOqkcpXWFMFMPiYXVGieBKYXpeHdcDHFyGFl1GCBNEl_sDoC8w5ximXT-82Rz30y74Ywb0rYgBuYTcQre9zyGi0KHLkPJd7_s-gUuFBj_HCKMH1I9onYqd24Ib0MqVWnxcPejckODJzXpR_fiw_r76VG--fvy8erepvZAq1xKUNoLoDpsOe88aBUqCVtBS3bRUSeaNkYJKz3nrWGN41_mO01Zhz0XD2EX19uQ7zc0eWg9jjm6wU-z3Lh5tcL39Uxn7nd2Gg2XEUMNUMXhxYxDD9Qwp232fPAyDGyHMyWqjBWaa8kK-_C9JuOQCK2J0QZ__hV6FOY7lIYqf0kQTtkDkBPkYUorQ3Z6aYLskwJ4SYEsC7JIAu_Q8-_26tx2_vrwA9ASkIo1biHeT_-36ExY2vgU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>897818138</pqid></control><display><type>article</type><title>Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Sharaiha, Reem Z. ; Halazun, Karim J. ; Mirza, Farooq ; Port, Jeffrey L. ; Lee, Paul C. ; Neugut, Alfred I. ; Altorki, Nasser K. ; Abrams, Julian A.</creator><creatorcontrib>Sharaiha, Reem Z. ; Halazun, Karim J. ; Mirza, Farooq ; Port, Jeffrey L. ; Lee, Paul C. ; Neugut, Alfred I. ; Altorki, Nasser K. ; Abrams, Julian A.</creatorcontrib><description>Background
The prognosis for patients with esophageal cancer is poor, even among those who undergo potentially curative esophagectomy. The neutrophil:lymphocyte ratio (NLR) is hypothesized to reflect the systemic inflammatory response created by a tumor and is possibly predictive of tumor aggressiveness and propensity for metastasis.
Methods
We performed a single-center retrospective analysis of esophageal cancer patients who underwent attempted curative esophagectomy at Weill Cornell Medical Center between 1996 and 2009. We collected data on patient demographics, clinical characteristics, and receipt of neoadjuvant treatment. Preoperative blood tests were used to calculate NLR. Elevated NLR was defined a priori as ≥5.0. Logistic regression modeling was performed to analyze characteristics associated with elevated NLR. We conducted Kaplan-Meier analyses and Cox regression modeling to determine estimates and predictors of disease-free and overall survival.
Results
We identified a total of 295 patients who underwent esophagectomy. The median duration of follow-up was 31 months (interquartile range [IQR] 13–61). There were 56 patients (18.9%) who had elevated NLR preoperatively. Receipt of neoadjuvant therapy was independently associated with high NLR (odds ratio [OR] 2.14, 95% confidence interval [95% CI] 1.02–4.51). In multivariable analyses, elevated NLR was associated with significantly worse disease-free (hazard ratio [HR] 2.26, 95% CI 1.43–3.55) and overall survival (HR 2.31, 95% CI 1.53–3.50).
Conclusions
Preoperative NLR is a potential prognostic marker for recurrence and death after esophagectomy. It is unclear whether NLR reflects the degree of inflammatory response to the primary tumor or other patient-specific or tumor characteristics that predispose to recurrence. Further investigation is warranted to clarify the mechanisms explaining the observed associations between elevated NLR and poor outcomes in esophageal cancer.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-011-1754-8</identifier><identifier>PMID: 21547702</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy ; Female ; Follow-Up Studies ; Gastrointestinal Oncology ; Humans ; Lymphocytes - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Neutrophils - pathology ; Oncology ; Postoperative Complications ; Postoperative Period ; Preoperative Period ; Prognosis ; Prospective Studies ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2011-11, Vol.18 (12), p.3362-3369</ispartof><rights>Society of Surgical Oncology 2011</rights><rights>Society of Surgical Oncology 2011 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-6e789518f09f0cc3b7e76e87ed28bd2763c996526c44da3b94ffcf42d70c45b33</citedby><cites>FETCH-LOGICAL-c567t-6e789518f09f0cc3b7e76e87ed28bd2763c996526c44da3b94ffcf42d70c45b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-011-1754-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-011-1754-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21547702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharaiha, Reem Z.</creatorcontrib><creatorcontrib>Halazun, Karim J.</creatorcontrib><creatorcontrib>Mirza, Farooq</creatorcontrib><creatorcontrib>Port, Jeffrey L.</creatorcontrib><creatorcontrib>Lee, Paul C.</creatorcontrib><creatorcontrib>Neugut, Alfred I.</creatorcontrib><creatorcontrib>Altorki, Nasser K.</creatorcontrib><creatorcontrib>Abrams, Julian A.</creatorcontrib><title>Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
The prognosis for patients with esophageal cancer is poor, even among those who undergo potentially curative esophagectomy. The neutrophil:lymphocyte ratio (NLR) is hypothesized to reflect the systemic inflammatory response created by a tumor and is possibly predictive of tumor aggressiveness and propensity for metastasis.
Methods
We performed a single-center retrospective analysis of esophageal cancer patients who underwent attempted curative esophagectomy at Weill Cornell Medical Center between 1996 and 2009. We collected data on patient demographics, clinical characteristics, and receipt of neoadjuvant treatment. Preoperative blood tests were used to calculate NLR. Elevated NLR was defined a priori as ≥5.0. Logistic regression modeling was performed to analyze characteristics associated with elevated NLR. We conducted Kaplan-Meier analyses and Cox regression modeling to determine estimates and predictors of disease-free and overall survival.
Results
We identified a total of 295 patients who underwent esophagectomy. The median duration of follow-up was 31 months (interquartile range [IQR] 13–61). There were 56 patients (18.9%) who had elevated NLR preoperatively. Receipt of neoadjuvant therapy was independently associated with high NLR (odds ratio [OR] 2.14, 95% confidence interval [95% CI] 1.02–4.51). In multivariable analyses, elevated NLR was associated with significantly worse disease-free (hazard ratio [HR] 2.26, 95% CI 1.43–3.55) and overall survival (HR 2.31, 95% CI 1.53–3.50).
Conclusions
Preoperative NLR is a potential prognostic marker for recurrence and death after esophagectomy. It is unclear whether NLR reflects the degree of inflammatory response to the primary tumor or other patient-specific or tumor characteristics that predispose to recurrence. Further investigation is warranted to clarify the mechanisms explaining the observed associations between elevated NLR and poor outcomes in esophageal cancer.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal Oncology</subject><subject>Humans</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Neutrophils - pathology</subject><subject>Oncology</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kkuLFDEUhQtRnHH0B7iR4EY3pXk_XAjStg9odBBdh1TqVncN1ZWaJNXQ_94UPc6ooKuEe757bh6nqp4S_IpQLl4ngjnjNSakJkrwWt-rzokoFS41uV_2WOraUCnOqkcpXWFMFMPiYXVGieBKYXpeHdcDHFyGFl1GCBNEl_sDoC8w5ximXT-82Rz30y74Ywb0rYgBuYTcQre9zyGi0KHLkPJd7_s-gUuFBj_HCKMH1I9onYqd24Ib0MqVWnxcPejckODJzXpR_fiw_r76VG--fvy8erepvZAq1xKUNoLoDpsOe88aBUqCVtBS3bRUSeaNkYJKz3nrWGN41_mO01Zhz0XD2EX19uQ7zc0eWg9jjm6wU-z3Lh5tcL39Uxn7nd2Gg2XEUMNUMXhxYxDD9Qwp232fPAyDGyHMyWqjBWaa8kK-_C9JuOQCK2J0QZ__hV6FOY7lIYqf0kQTtkDkBPkYUorQ3Z6aYLskwJ4SYEsC7JIAu_Q8-_26tx2_vrwA9ASkIo1biHeT_-36ExY2vgU</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Sharaiha, Reem Z.</creator><creator>Halazun, Karim J.</creator><creator>Mirza, Farooq</creator><creator>Port, Jeffrey L.</creator><creator>Lee, Paul C.</creator><creator>Neugut, Alfred I.</creator><creator>Altorki, Nasser K.</creator><creator>Abrams, Julian A.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer</title><author>Sharaiha, Reem Z. ; Halazun, Karim J. ; Mirza, Farooq ; Port, Jeffrey L. ; Lee, Paul C. ; Neugut, Alfred I. ; Altorki, Nasser K. ; Abrams, Julian A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-6e789518f09f0cc3b7e76e87ed28bd2763c996526c44da3b94ffcf42d70c45b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal Oncology</topic><topic>Humans</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Neutrophils - pathology</topic><topic>Oncology</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharaiha, Reem Z.</creatorcontrib><creatorcontrib>Halazun, Karim J.</creatorcontrib><creatorcontrib>Mirza, Farooq</creatorcontrib><creatorcontrib>Port, Jeffrey L.</creatorcontrib><creatorcontrib>Lee, Paul C.</creatorcontrib><creatorcontrib>Neugut, Alfred I.</creatorcontrib><creatorcontrib>Altorki, Nasser K.</creatorcontrib><creatorcontrib>Abrams, Julian A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharaiha, Reem Z.</au><au>Halazun, Karim J.</au><au>Mirza, Farooq</au><au>Port, Jeffrey L.</au><au>Lee, Paul C.</au><au>Neugut, Alfred I.</au><au>Altorki, Nasser K.</au><au>Abrams, Julian A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>18</volume><issue>12</issue><spage>3362</spage><epage>3369</epage><pages>3362-3369</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
The prognosis for patients with esophageal cancer is poor, even among those who undergo potentially curative esophagectomy. The neutrophil:lymphocyte ratio (NLR) is hypothesized to reflect the systemic inflammatory response created by a tumor and is possibly predictive of tumor aggressiveness and propensity for metastasis.
Methods
We performed a single-center retrospective analysis of esophageal cancer patients who underwent attempted curative esophagectomy at Weill Cornell Medical Center between 1996 and 2009. We collected data on patient demographics, clinical characteristics, and receipt of neoadjuvant treatment. Preoperative blood tests were used to calculate NLR. Elevated NLR was defined a priori as ≥5.0. Logistic regression modeling was performed to analyze characteristics associated with elevated NLR. We conducted Kaplan-Meier analyses and Cox regression modeling to determine estimates and predictors of disease-free and overall survival.
Results
We identified a total of 295 patients who underwent esophagectomy. The median duration of follow-up was 31 months (interquartile range [IQR] 13–61). There were 56 patients (18.9%) who had elevated NLR preoperatively. Receipt of neoadjuvant therapy was independently associated with high NLR (odds ratio [OR] 2.14, 95% confidence interval [95% CI] 1.02–4.51). In multivariable analyses, elevated NLR was associated with significantly worse disease-free (hazard ratio [HR] 2.26, 95% CI 1.43–3.55) and overall survival (HR 2.31, 95% CI 1.53–3.50).
Conclusions
Preoperative NLR is a potential prognostic marker for recurrence and death after esophagectomy. It is unclear whether NLR reflects the degree of inflammatory response to the primary tumor or other patient-specific or tumor characteristics that predispose to recurrence. Further investigation is warranted to clarify the mechanisms explaining the observed associations between elevated NLR and poor outcomes in esophageal cancer.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21547702</pmid><doi>10.1245/s10434-011-1754-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2011-11, Vol.18 (12), p.3362-3369 |
| issn | 1068-9265 1534-4681 |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Esophagectomy Female Follow-Up Studies Gastrointestinal Oncology Humans Lymphocytes - pathology Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - surgery Neoplasm Staging Neutrophils - pathology Oncology Postoperative Complications Postoperative Period Preoperative Period Prognosis Prospective Studies Retrospective Studies Surgery Surgical Oncology Survival Rate |
| title | Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer |
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