Aerobic exercise reverses arterial inflammation with aging in mice

We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. When compared with young controls (6.2 ± 0.4 mo; n = 7), old (31.3 ± 0.5 mo; n = 11) male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the proinflammatory transcription fact...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2011-09, Vol.301 (3), p.H1025-H1032
Hauptverfasser:	Lesniewski, Lisa A, Durrant, Jessica R, Connell, Melanie L, Henson, Grant D, Black, Alexander D, Donato, Anthony J, Seals, Douglas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Aging - immunology Analysis of Variance Animals Aorta, Thoracic - immunology Aortitis - immunology Aortitis - physiopathology Aortitis - therapy Arteritis - immunology Arteritis - physiopathology Arteritis - therapy Carotid Arteries - immunology Carotid Arteries - physiopathology Exercise I-kappa B Kinase - metabolism Inflammation Mediators - metabolism Integrative Cardiovascular Physiology and Pathophysiology Interferon-gamma - metabolism Interleukin-1 - metabolism Interleukin-6 - metabolism Least-Squares Analysis Lymphocytes Macrophages - immunology Male Mice Phenotype Phosphorylation Physical Exertion Rodents T-Lymphocytes - immunology Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - metabolism Vasodilation Veins & arteries
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