Structure and Mechanism of the Diiron Benzoyl-Coenzyme A Epoxidase BoxB

The coenzyme A (CoA)-dependent aerobic benzoate metabolic pathway uses an unprecedented chemical strategy to overcome the high aromatic resonance energy by forming the non-aromatic 2,3-epoxybenzoyl-CoA. The crucial dearomatizing reaction is catalyzed by three enzymes, BoxABC, where BoxA is an NADPH-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2011-08, Vol.286 (33), p.29241-29248
Hauptverfasser:	Rather, Liv J., Weinert, Tobias, Demmer, Ulrike, Bill, Eckhard, Ismail, Wael, Fuchs, Georg, Ermler, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Acyl Coenzyme A - metabolism Aromatic Metabolism Azoarcus - enzymology Benzoates - metabolism BoxB Coenzyme A Crystallography, X-Ray Diiron Center Energy Metabolism Enzyme Mechanisms Enzyme Structure Enzymology Epoxide Iron - chemistry Iron - metabolism Oxidase Oxidoreductases - chemistry Oxidoreductases - metabolism Oxygen - chemistry Oxygen - metabolism Oxygen Radicals Protein Structure, Tertiary Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!