Impaired Spermatogenesis and Fertility in Mice Carrying a Mutation in the Spink2 Gene Expressed Predominantly in Testes

Spermatogenesis is a complex process involving an intrinsic genetic program composed of germ cell-specific and -predominant genes. In this study, we investigated the mouse Spink2 (serine protease inhibitor Kazal-type 2) gene, which belongs to the SPINK family of proteins characterized by the presenc...

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Veröffentlicht in:	The Journal of biological chemistry 2011-08, Vol.286 (33), p.29108-29117
Hauptverfasser:	Lee, Boyeon, Park, Inju, Jin, Sora, Choi, Heejin, Kwon, Jun Tae, Kim, Jihye, Jeong, Juri, Cho, Byung-Nam, Eddy, Edward M., Cho, Chunghee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Developmental Biology Fertility Fertility - physiology Glycoproteins - biosynthesis Glycoproteins - genetics Infertility Male Mice Mice, Inbred ICR Mice, Mutant Strains Mutagenesis Organ Specificity - physiology Protease Protease Inhibitor Reproduction Serine Peptidase Inhibitors, Kazal Type Serine Protease Serpins - biosynthesis Serpins - genetics Sperm Spermatogenesis Spermatogenesis - physiology Spermatozoa - cytology Spermatozoa - metabolism Testis Testis - cytology Testis - metabolism Transcription, Genetic - physiology
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