Engineering Polymeric Aptamers for Selective Cytotoxicity

Chemotherapy strategies thus far reported can result in both side effects and drug resistance. To address both of these issues at the cellular level, we report a molecular engineering strategy, which employs polymeric aptamers to induce selective cytotoxicity inside target cells. The polymeric aptam...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-08, Vol.133 (34), p.13380-13386
Hauptverfasser:	Yang, Liu, Meng, Ling, Zhang, Xiaobing, Chen, Yan, Zhu, Guizhi, Liu, Haipeng, Xiong, Xiangling, Sefah, Kwame, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - therapeutic use Cell Line, Tumor Cell Survival - drug effects Drug Delivery Systems Humans Neoplasms - drug therapy Polymers - administration & dosage Polymers - chemistry Polymers - therapeutic use SELEX Aptamer Technique - methods
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