Colloidal Gold-Low Density Lipoprotein Conjugates as Membrane Receptor Probes

We have developed a method for conjugating low density lipoproteins (LDL) with colloidal gold. Conjugation, complete after 1 min, occurs by electrostatic adsorption of the LDL to the negatively charged gold particle. Each conjugate consists of approximately eight biologically active LDL molecules cl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1981-01, Vol.78 (1), p.368-371
Hauptverfasser:	Handley, Dean A., Arbeeny, Cynthia M., Witte, Larry D., Chien, Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - ultrastructure Cells, Cultured Colloids Endocytosis Fibroblasts Fibroblasts - metabolism Gold - metabolism Gold collolid Humans Hypercholesterolemia - metabolism Internalization Lipoproteins Lipoproteins, LDL - metabolism Lysosomes Lysosomes - metabolism Microscopy, Electron Molecules Negative staining Receptors Receptors, Cell Surface - metabolism Receptors, LDL Ruthenium
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