p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

The signaling adaptor p62 is a critical mediator of important cellular functions, owing to its ability to establish interactions with various signaling intermediaries. Here, we identify raptor as an interacting partner of p62. Thus, p62 is an integral part of the mTORC1 complex and is necessary to m...

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Veröffentlicht in:	Molecular cell 2011-10, Vol.44 (1), p.134-146
Hauptverfasser:	Duran, Angeles, Amanchy, Ramars, Linares, Juan F., Joshi, Jayashree, Abu-Baker, Shadi, Porollo, Aleksey, Hansen, Malene, Moscat, Jorge, Diaz-Meco, Maria T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism amino acids Animals Autophagy birds of prey Carrier Proteins - metabolism Dimerization GTP Phosphohydrolases - metabolism guanosinetriphosphatase Heat-Shock Proteins - metabolism HEK293 Cells Humans lysosomes Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 Mice Multiprotein Complexes NIH 3T3 Cells Plasmids - metabolism Protein Kinase C - metabolism proteins Proteins - metabolism Regulatory-Associated Protein of mTOR Sequestosome-1 Protein TOR Serine-Threonine Kinases
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