A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase SET8, are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase CRL4CDT2. CRL4CDT2 function is coupled to replication and repair because it only ubiquitinates substrate...

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Veröffentlicht in:	Molecular cell 2011-10, Vol.44 (1), p.72-84
Hauptverfasser:	Raman, Malavika, Havens, Courtney G., Walter, Johannes C., Harper, J. Wade
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Cell Cycle Proteins - metabolism Chromatin Chromatin - metabolism DNA DNA Damage DNA repair DNA replication DNA-Binding Proteins - metabolism eggs Gene Expression Regulation Genome, Human HeLa Cells Histone-Lysine N-Methyltransferase - metabolism histones Humans methyltransferases Nuclear Proteins - metabolism proliferating cell nuclear antigen Proteasome Endopeptidase Complex - metabolism proteolysis RNA, Small Interfering - metabolism small interfering RNA ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism ultraviolet radiation Valosin Containing Protein Xenopus Xenopus laevis Xenopus Proteins - metabolism
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