Translation initiation: a regulatory role for poly(A) tracts in front of the AUG codon in Saccharomyces cerevisiae

The 5'-UTR serves as the loading dock for ribosomes during translation initiation and is the key site for translation regulation. Many genes in the yeast Saccharomyces cerevisiae contain poly(A) tracts in their 5'-UTRs. We studied these pre-AUG poly(A) tracts in a set of 3274 recently iden...

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Veröffentlicht in:	Genetics (Austin) 2011-10, Vol.189 (2), p.469-478
Hauptverfasser:	Xia, Xuhua, MacKay, Vivian, Yao, Xiaoquan, Wu, Jianhua, Miura, Fumihito, Ito, Takashi, Morris, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Base Sequence Binding sites Binding Sites - genetics Codon - genetics Efficiency Frequency distribution Gene expression Genetics Genomes Infections Investigations Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Poly A - genetics Poly A - metabolism Poly(A)-Binding Proteins - genetics Poly(A)-Binding Proteins - metabolism Protein Binding Protein Biosynthesis - genetics Protein synthesis Proteins Ribosomes - genetics Ribosomes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Studies Viral infections
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