Anti‐platelet therapy: ADP receptor antagonists
The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided tha...
Gespeichert in:
| Veröffentlicht in: | British journal of clinical pharmacology 2011-10, Vol.72 (4), p.647-657 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 657 |
|---|---|
| container_issue | 4 |
| container_start_page | 647 |
| container_title | British journal of clinical pharmacology |
| container_volume | 72 |
| creator | Wijeyeratne, Yanushi Dullewe Heptinstall, Stan |
| description | The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function. |
| doi_str_mv | 10.1111/j.1365-2125.2011.03999.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3187865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>889176208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4739-7563f3c59329e73767f87caee2671817318909b91168d21ab9ce393969b554db3</originalsourceid><addsrcrecordid>eNqNkM1O4zAQxy0EggL7Cig3TgkeG38hgVS6fElI9MCeLSedQqo0CbYL9LaPwDPuk2xCS7Xc1pexNP_5zehHSAI0g-6dzDLgUqQMmMgYBcgoN8Zk71tksGlskwHlVKaCCdgj-yHMKAUOUuySPQYCNNdmQGBYx_LP74-2chErjEl8Ru_a5Vky_DlOPBbYxsYnro7uqanLEMMh2Zm6KuCPdT0gv66vHke36f3Dzd1oeJ8Wp4qbVAnJp7wQhjODiiupploVDpFJBRoUB22oyQ2A1BMGLjcFcsONNLkQp5OcH5CLFbdd5HOcFFhH7yrb-nLu_NI2rrTfO3X5bJ-aV9uRlZaiAxyvAb55WWCIdl6GAqvK1dgsgtXagJKM6i6pV8nCNyF4nG62ALW9cDuzvVfbe7W9cPsp3L53o0f_XrkZ_DLcBc5XgbeywuV_g-3laNz_-F8RuY8M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>889176208</pqid></control><display><type>article</type><title>Anti‐platelet therapy: ADP receptor antagonists</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Wijeyeratne, Yanushi Dullewe ; Heptinstall, Stan</creator><creatorcontrib>Wijeyeratne, Yanushi Dullewe ; Heptinstall, Stan</creatorcontrib><description>The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.2011.03999.x</identifier><identifier>PMID: 21518389</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>anti‐platelet ; Blood Platelets - drug effects ; cangrelor ; clopidogrel ; Haemostasis Themed Issue ; Humans ; P2Y12 ; platelet ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; prasugrel ; Purinergic P2Y Receptor Antagonists - pharmacology ; Thrombosis - prevention & control ; ticagrelor</subject><ispartof>British journal of clinical pharmacology, 2011-10, Vol.72 (4), p.647-657</ispartof><rights>2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society</rights><rights>2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.</rights><rights>Copyright © 2011 The British Pharmacological Society 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4739-7563f3c59329e73767f87caee2671817318909b91168d21ab9ce393969b554db3</citedby><cites>FETCH-LOGICAL-c4739-7563f3c59329e73767f87caee2671817318909b91168d21ab9ce393969b554db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2125.2011.03999.x$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2125.2011.03999.x$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21518389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wijeyeratne, Yanushi Dullewe</creatorcontrib><creatorcontrib>Heptinstall, Stan</creatorcontrib><title>Anti‐platelet therapy: ADP receptor antagonists</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.</description><subject>anti‐platelet</subject><subject>Blood Platelets - drug effects</subject><subject>cangrelor</subject><subject>clopidogrel</subject><subject>Haemostasis Themed Issue</subject><subject>Humans</subject><subject>P2Y12</subject><subject>platelet</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>prasugrel</subject><subject>Purinergic P2Y Receptor Antagonists - pharmacology</subject><subject>Thrombosis - prevention & control</subject><subject>ticagrelor</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqNkM1O4zAQxy0EggL7Cig3TgkeG38hgVS6fElI9MCeLSedQqo0CbYL9LaPwDPuk2xCS7Xc1pexNP_5zehHSAI0g-6dzDLgUqQMmMgYBcgoN8Zk71tksGlskwHlVKaCCdgj-yHMKAUOUuySPQYCNNdmQGBYx_LP74-2chErjEl8Ru_a5Vky_DlOPBbYxsYnro7uqanLEMMh2Zm6KuCPdT0gv66vHke36f3Dzd1oeJ8Wp4qbVAnJp7wQhjODiiupploVDpFJBRoUB22oyQ2A1BMGLjcFcsONNLkQp5OcH5CLFbdd5HOcFFhH7yrb-nLu_NI2rrTfO3X5bJ-aV9uRlZaiAxyvAb55WWCIdl6GAqvK1dgsgtXagJKM6i6pV8nCNyF4nG62ALW9cDuzvVfbe7W9cPsp3L53o0f_XrkZ_DLcBc5XgbeywuV_g-3laNz_-F8RuY8M</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Wijeyeratne, Yanushi Dullewe</creator><creator>Heptinstall, Stan</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201110</creationdate><title>Anti‐platelet therapy: ADP receptor antagonists</title><author>Wijeyeratne, Yanushi Dullewe ; Heptinstall, Stan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4739-7563f3c59329e73767f87caee2671817318909b91168d21ab9ce393969b554db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>anti‐platelet</topic><topic>Blood Platelets - drug effects</topic><topic>cangrelor</topic><topic>clopidogrel</topic><topic>Haemostasis Themed Issue</topic><topic>Humans</topic><topic>P2Y12</topic><topic>platelet</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>prasugrel</topic><topic>Purinergic P2Y Receptor Antagonists - pharmacology</topic><topic>Thrombosis - prevention & control</topic><topic>ticagrelor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wijeyeratne, Yanushi Dullewe</creatorcontrib><creatorcontrib>Heptinstall, Stan</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wijeyeratne, Yanushi Dullewe</au><au>Heptinstall, Stan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti‐platelet therapy: ADP receptor antagonists</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>72</volume><issue>4</issue><spage>647</spage><epage>657</epage><pages>647-657</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21518389</pmid><doi>10.1111/j.1365-2125.2011.03999.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 2011-10, Vol.72 (4), p.647-657 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3187865 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | anti‐platelet Blood Platelets - drug effects cangrelor clopidogrel Haemostasis Themed Issue Humans P2Y12 platelet Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology prasugrel Purinergic P2Y Receptor Antagonists - pharmacology Thrombosis - prevention & control ticagrelor |
| title | Anti‐platelet therapy: ADP receptor antagonists |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T20%3A39%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti%E2%80%90platelet%20therapy:%20ADP%20receptor%20antagonists&rft.jtitle=British%20journal%20of%20clinical%20pharmacology&rft.au=Wijeyeratne,%20Yanushi%20Dullewe&rft.date=2011-10&rft.volume=72&rft.issue=4&rft.spage=647&rft.epage=657&rft.pages=647-657&rft.issn=0306-5251&rft.eissn=1365-2125&rft_id=info:doi/10.1111/j.1365-2125.2011.03999.x&rft_dat=%3Cproquest_pubme%3E889176208%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=889176208&rft_id=info:pmid/21518389&rfr_iscdi=true |