New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei

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Veröffentlicht in:	Applied and Environmental Microbiology 2011-09, Vol.77 (18), p.6636-6643
Hauptverfasser:	BRAUTASET, Trygve, SLETTA, Havard, DEGNES, Kristin F, SEKUROVA, Olga N, BAKKE, Ingrid, VOLOKHAN, Olga, ANDREASSEN, Trygve, ELLINGSEN, Trond E, ZOTCHEV, Sergey B
Format:	Artikel
Sprache:	eng
Schlagworte:	amphotericin B Animals Antibiotics Antifungal Agents - chemistry Antifungal Agents - metabolism Antifungal Agents - pharmacology Antifungal Agents - toxicity antifungal properties Biological and medical sciences Biosynthesis Biosynthetic Pathways - genetics Biotechnology Candida albicans - drug effects engineering Erythrocytes - drug effects Fundamental and applied biological sciences. Psychology Fungal infections Gram-positive bacteria Hemolysis Horses Macrolides - chemistry Macrolides - metabolism Macrolides - pharmacology Macrolides - toxicity Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Models, Molecular Molecular Structure nystatin Nystatin - analogs & derivatives Nystatin - chemistry Nystatin - metabolism Nystatin - pharmacology Nystatin - toxicity Polyenes - chemistry Polyenes - metabolism Polyenes - pharmacology Polyenes - toxicity Polymers - chemistry Polymers - metabolism Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism Streptomyces noursei toxicity
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