Catabolism of 4-hydroxy-2- trans-nonenal by THP1 monocytes/macrophages and inactivation of carboxylesterases by this lipid electrophile

► Effects of 4-hydroxynonenal (HNE) on esterase and lipase activities was examined. ► Hydrolytic activities of pure CES enzymes and intact cells are inhibited by HNE. ► Lysine 105 in recombinant CES1 enzyme was covalently modified by HNE. ► THP1 cells efficiently metabolize HNE and yield glutathione...

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Veröffentlicht in:	Chemico-biological interactions 2011-10, Vol.194 (1), p.1-12
Hauptverfasser:	Borazjani, Abdolsamad, Edelmann, Mariola J., Hardin, Katelyn L., Herring, Katye L., Allen Crow, J., Ross, Matthew K.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Aldehydes - metabolism Aldehydes - pharmacology Atherosclerosis - metabolism Atherosclerosis - pathology Carboxylesterases Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - metabolism Cell Line Cysteine Proteinase Inhibitors - metabolism Cysteine Proteinase Inhibitors - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Humans Inflammation - metabolism Inflammation - pathology Lipid Metabolism - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Monocytes - cytology Monocytes - drug effects Monocytes - metabolism THP1 macrophages THP1 monocytes Time Factors
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