Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice

Background & Aims Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer, is associated with increased levels of cell stress. Pancreatic acinar cells are involved in development of these diseases and, because of their high level of protein output, they require an...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-10, Vol.141 (4), p.1463-1472
Hauptverfasser:	Hess, David A, Humphrey, Sean E, Ishibashi, Jeff, Damsz, Barbara, Lee, Ann–Hwee, Glimcher, Laurie H, Konieczny, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Lineage Cell Proliferation DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress Gastroenterology and Hepatology Homeodomain Proteins - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Pancreas, Exocrine - metabolism Pancreas, Exocrine - pathology Pancreatic Diseases - genetics Pancreatic Diseases - metabolism Pancreatic Diseases - pathology Pancreatic Progenitor Cells Protein Folding Protein-Serine-Threonine Kinases - metabolism Regeneration Regulatory Factor X Transcription Factors SOX9 Transcription Factor - metabolism Stress, Physiological Time Factors Tissue Regeneration Transcription Factor HES-1 Transcription Factors - deficiency Transcription Factors - genetics Unfolded Protein Response X-Box Binding Protein 1
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