Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression
Objective Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhood–onset MDD. Method A total of 5...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 2011-10, Vol.50 (10), p.1027-1041.e3 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1041.e3 |
|---|---|
| container_issue | 10 |
| container_start_page | 1027 |
| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
| container_volume | 50 |
| creator | Luking, Katherine R., B.S Repovs, Grega, Ph.D Belden, Andy C., Ph.D Gaffrey, Michael S., Ph.D Botteron, Kelly N., M.D Luby, Joan L., M.D Barch, Deanna M., Ph.D |
| description | Objective Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhood–onset MDD. Method A total of 51 children 7 through 11 years of age who had been prospectively studied since preschool age, completed resting state functional magnetic resonance imaging (fMRI) and were assigned to one of four groups: 1) C-MDD (N = 13), those children with a personal history of early-childhood–onset MDD; 2) M-MDD (N = 11), those with a maternal history of affective disorders; 3) CM-MDD (N = 13), those with both maternal and early-childhood–onset MDD; or 4) CON (N = 14), those without either a personal or maternal history of MDD. We used seed-based resting state functional connectivity (rsfcMRI) analysis in an independent sample of adults to identify networks showing both positive (e.g., limbic regions) and negative (e.g., dorsal frontal/parietal regions) connectivity with the amygdala. These regions were then used in region-of-interest–based analyses of our child sample. Results We found a significant interaction between maternal affective disorder history and the child's MDD history for both positive and negative rsfcMRI networks. Specifically, when compared with CON, we found reduced connectivity between the amygdala and the “negative network” in children with C-MDD, M-MDD, and CM-MDD. Children with either C-MDD or a maternal history of MDD (but not CM-MDD) displayed reduced connectivity between the amygdala and the “positive network.” Conclusions Our finding of an attenuated relationship between the amygdala, a region affected in MDD and involved in emotion processing, and cognitive control regions is consistent with a hypothesis of altered regulation of emotional processing in C-MDD, suggesting developmental continuity of this alteration into early childhood. |
| doi_str_mv | 10.1016/j.jaac.2011.07.019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3185293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ericid>EJ941614</ericid><els_id>1_s2_0_S0890856711006496</els_id><sourcerecordid>896241764</sourcerecordid><originalsourceid>FETCH-LOGICAL-c718t-9a7b63ecc93973d080158b378d12e980b3a57b4192939d3af02db489463d0bfd3</originalsourceid><addsrcrecordid>eNqFkltvEzEQhVcIREvgDyCEVkgIXjbMeHd9kVClKqTcKvUBeLa8Xm_jsLFTexMp_x5vEwL0oTxZ1nxzNDPnZNlzhCkC0nfL6VIpPSWAOAU2BRQPslOsCSvqCvnD7BS4gILXlJ1kT2JcAgAyzh9nJwQFRcbYafb1YuP0YL1TfT7zzpn02dphl_suHxYmP1_trlvVq9y6fK5CvytmC9u3C-_b4spFM-QfzDqYGJPE0-xRp_ponh3eSfbjYv599qm4vPr4eXZ-WWiGfCiEYg0tjdaiFKxsgQPWvCkZb5EYwaEpVc2aCgVJQFuqDkjbVFxUNMFN15aT7Gyvu940K9Nq44agerkOdqXCTnpl5b8VZxfy2m9libxOokngzUEg-JuNiYNc2ahN3ytn_CZKAaSkQFH8l-SCkgoZrRL59l4SoQQBFUkrT7JXd9Cl34TkwK2ewIpwmiCyh3TwMQbTHfdDkKP9cilH--VovwQm4Xbcl39f5tjy2-8EvD4AKmrVd0E5beMfrqJIUmAS92LPmWD1sTz_IiqkOC77_lBONm-tCTJqa5w2rQ0pQbL19v4xz-606946mwb6aXYmHq-BMhIJ8tuY4zHGiAC0ErT8Bajw6oM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>896914286</pqid></control><display><type>article</type><title>Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Access via ScienceDirect (Elsevier)</source><creator>Luking, Katherine R., B.S ; Repovs, Grega, Ph.D ; Belden, Andy C., Ph.D ; Gaffrey, Michael S., Ph.D ; Botteron, Kelly N., M.D ; Luby, Joan L., M.D ; Barch, Deanna M., Ph.D</creator><creatorcontrib>Luking, Katherine R., B.S ; Repovs, Grega, Ph.D ; Belden, Andy C., Ph.D ; Gaffrey, Michael S., Ph.D ; Botteron, Kelly N., M.D ; Luby, Joan L., M.D ; Barch, Deanna M., Ph.D</creatorcontrib><description>Objective Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhood–onset MDD. Method A total of 51 children 7 through 11 years of age who had been prospectively studied since preschool age, completed resting state functional magnetic resonance imaging (fMRI) and were assigned to one of four groups: 1) C-MDD (N = 13), those children with a personal history of early-childhood–onset MDD; 2) M-MDD (N = 11), those with a maternal history of affective disorders; 3) CM-MDD (N = 13), those with both maternal and early-childhood–onset MDD; or 4) CON (N = 14), those without either a personal or maternal history of MDD. We used seed-based resting state functional connectivity (rsfcMRI) analysis in an independent sample of adults to identify networks showing both positive (e.g., limbic regions) and negative (e.g., dorsal frontal/parietal regions) connectivity with the amygdala. These regions were then used in region-of-interest–based analyses of our child sample. Results We found a significant interaction between maternal affective disorder history and the child's MDD history for both positive and negative rsfcMRI networks. Specifically, when compared with CON, we found reduced connectivity between the amygdala and the “negative network” in children with C-MDD, M-MDD, and CM-MDD. Children with either C-MDD or a maternal history of MDD (but not CM-MDD) displayed reduced connectivity between the amygdala and the “positive network.” Conclusions Our finding of an attenuated relationship between the amygdala, a region affected in MDD and involved in emotion processing, and cognitive control regions is consistent with a hypothesis of altered regulation of emotional processing in C-MDD, suggesting developmental continuity of this alteration into early childhood.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1016/j.jaac.2011.07.019</identifier><identifier>PMID: 21961777</identifier><identifier>CODEN: JAAPEE</identifier><language>eng</language><publisher>Maryland Heights, MO: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Affective disorders ; Age of Onset ; amygdala ; Amygdala - physiopathology ; Biological and medical sciences ; Brain Hemisphere Functions ; Cerebral Cortex - physiopathology ; Child ; Child clinical studies ; Child psychology ; childhood-onset ; Children ; Cognitive Processes ; Correlation ; Depression ; Depression (Psychology) ; Depressive Disorder, Major - classification ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - physiopathology ; Depressive personality disorders ; Developmental Continuity ; Diagnostic Tests ; Disease Susceptibility ; Emotions ; Female ; fMRI ; Follow-Up Studies ; Functional connectivity ; Humans ; Limbic System - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mental depression ; Mood disorders ; Mothers ; Mothers - psychology ; Nerve Net - physiopathology ; NMR ; Nuclear magnetic resonance ; Pediatrics ; Preschool children ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Resting ; Risk ; Self Control ; Severity of Illness Index ; Sexual Abuse ; Young Children</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2011-10, Vol.50 (10), p.1027-1041.e3</ispartof><rights>American Academy of Child and Adolescent Psychiatry</rights><rights>2011 American Academy of Child and Adolescent Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Lippincott Williams & Wilkins Oct 2011</rights><rights>2011 American Academy of Child & Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-9a7b63ecc93973d080158b378d12e980b3a57b4192939d3af02db489463d0bfd3</citedby><cites>FETCH-LOGICAL-c718t-9a7b63ecc93973d080158b378d12e980b3a57b4192939d3af02db489463d0bfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaac.2011.07.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,31004,31005,46000</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ941614$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24612856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21961777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luking, Katherine R., B.S</creatorcontrib><creatorcontrib>Repovs, Grega, Ph.D</creatorcontrib><creatorcontrib>Belden, Andy C., Ph.D</creatorcontrib><creatorcontrib>Gaffrey, Michael S., Ph.D</creatorcontrib><creatorcontrib>Botteron, Kelly N., M.D</creatorcontrib><creatorcontrib>Luby, Joan L., M.D</creatorcontrib><creatorcontrib>Barch, Deanna M., Ph.D</creatorcontrib><title>Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>Objective Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhood–onset MDD. Method A total of 51 children 7 through 11 years of age who had been prospectively studied since preschool age, completed resting state functional magnetic resonance imaging (fMRI) and were assigned to one of four groups: 1) C-MDD (N = 13), those children with a personal history of early-childhood–onset MDD; 2) M-MDD (N = 11), those with a maternal history of affective disorders; 3) CM-MDD (N = 13), those with both maternal and early-childhood–onset MDD; or 4) CON (N = 14), those without either a personal or maternal history of MDD. We used seed-based resting state functional connectivity (rsfcMRI) analysis in an independent sample of adults to identify networks showing both positive (e.g., limbic regions) and negative (e.g., dorsal frontal/parietal regions) connectivity with the amygdala. These regions were then used in region-of-interest–based analyses of our child sample. Results We found a significant interaction between maternal affective disorder history and the child's MDD history for both positive and negative rsfcMRI networks. Specifically, when compared with CON, we found reduced connectivity between the amygdala and the “negative network” in children with C-MDD, M-MDD, and CM-MDD. Children with either C-MDD or a maternal history of MDD (but not CM-MDD) displayed reduced connectivity between the amygdala and the “positive network.” Conclusions Our finding of an attenuated relationship between the amygdala, a region affected in MDD and involved in emotion processing, and cognitive control regions is consistent with a hypothesis of altered regulation of emotional processing in C-MDD, suggesting developmental continuity of this alteration into early childhood.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affective disorders</subject><subject>Age of Onset</subject><subject>amygdala</subject><subject>Amygdala - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain Hemisphere Functions</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child psychology</subject><subject>childhood-onset</subject><subject>Children</subject><subject>Cognitive Processes</subject><subject>Correlation</subject><subject>Depression</subject><subject>Depression (Psychology)</subject><subject>Depressive Disorder, Major - classification</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive personality disorders</subject><subject>Developmental Continuity</subject><subject>Diagnostic Tests</subject><subject>Disease Susceptibility</subject><subject>Emotions</subject><subject>Female</subject><subject>fMRI</subject><subject>Follow-Up Studies</subject><subject>Functional connectivity</subject><subject>Humans</subject><subject>Limbic System - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mood disorders</subject><subject>Mothers</subject><subject>Mothers - psychology</subject><subject>Nerve Net - physiopathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pediatrics</subject><subject>Preschool children</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Resting</subject><subject>Risk</subject><subject>Self Control</subject><subject>Severity of Illness Index</subject><subject>Sexual Abuse</subject><subject>Young Children</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkltvEzEQhVcIREvgDyCEVkgIXjbMeHd9kVClKqTcKvUBeLa8Xm_jsLFTexMp_x5vEwL0oTxZ1nxzNDPnZNlzhCkC0nfL6VIpPSWAOAU2BRQPslOsCSvqCvnD7BS4gILXlJ1kT2JcAgAyzh9nJwQFRcbYafb1YuP0YL1TfT7zzpn02dphl_suHxYmP1_trlvVq9y6fK5CvytmC9u3C-_b4spFM-QfzDqYGJPE0-xRp_ponh3eSfbjYv599qm4vPr4eXZ-WWiGfCiEYg0tjdaiFKxsgQPWvCkZb5EYwaEpVc2aCgVJQFuqDkjbVFxUNMFN15aT7Gyvu940K9Nq44agerkOdqXCTnpl5b8VZxfy2m9libxOokngzUEg-JuNiYNc2ahN3ytn_CZKAaSkQFH8l-SCkgoZrRL59l4SoQQBFUkrT7JXd9Cl34TkwK2ewIpwmiCyh3TwMQbTHfdDkKP9cilH--VovwQm4Xbcl39f5tjy2-8EvD4AKmrVd0E5beMfrqJIUmAS92LPmWD1sTz_IiqkOC77_lBONm-tCTJqa5w2rQ0pQbL19v4xz-606946mwb6aXYmHq-BMhIJ8tuY4zHGiAC0ErT8Bajw6oM</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Luking, Katherine R., B.S</creator><creator>Repovs, Grega, Ph.D</creator><creator>Belden, Andy C., Ph.D</creator><creator>Gaffrey, Michael S., Ph.D</creator><creator>Botteron, Kelly N., M.D</creator><creator>Luby, Joan L., M.D</creator><creator>Barch, Deanna M., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111001</creationdate><title>Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression</title><author>Luking, Katherine R., B.S ; Repovs, Grega, Ph.D ; Belden, Andy C., Ph.D ; Gaffrey, Michael S., Ph.D ; Botteron, Kelly N., M.D ; Luby, Joan L., M.D ; Barch, Deanna M., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-9a7b63ecc93973d080158b378d12e980b3a57b4192939d3af02db489463d0bfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affective disorders</topic><topic>Age of Onset</topic><topic>amygdala</topic><topic>Amygdala - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Hemisphere Functions</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child psychology</topic><topic>childhood-onset</topic><topic>Children</topic><topic>Cognitive Processes</topic><topic>Correlation</topic><topic>Depression</topic><topic>Depression (Psychology)</topic><topic>Depressive Disorder, Major - classification</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive personality disorders</topic><topic>Developmental Continuity</topic><topic>Diagnostic Tests</topic><topic>Disease Susceptibility</topic><topic>Emotions</topic><topic>Female</topic><topic>fMRI</topic><topic>Follow-Up Studies</topic><topic>Functional connectivity</topic><topic>Humans</topic><topic>Limbic System - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Mood disorders</topic><topic>Mothers</topic><topic>Mothers - psychology</topic><topic>Nerve Net - physiopathology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pediatrics</topic><topic>Preschool children</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Resting</topic><topic>Risk</topic><topic>Self Control</topic><topic>Severity of Illness Index</topic><topic>Sexual Abuse</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luking, Katherine R., B.S</creatorcontrib><creatorcontrib>Repovs, Grega, Ph.D</creatorcontrib><creatorcontrib>Belden, Andy C., Ph.D</creatorcontrib><creatorcontrib>Gaffrey, Michael S., Ph.D</creatorcontrib><creatorcontrib>Botteron, Kelly N., M.D</creatorcontrib><creatorcontrib>Luby, Joan L., M.D</creatorcontrib><creatorcontrib>Barch, Deanna M., Ph.D</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luking, Katherine R., B.S</au><au>Repovs, Grega, Ph.D</au><au>Belden, Andy C., Ph.D</au><au>Gaffrey, Michael S., Ph.D</au><au>Botteron, Kelly N., M.D</au><au>Luby, Joan L., M.D</au><au>Barch, Deanna M., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ941614</ericid><atitle>Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>50</volume><issue>10</issue><spage>1027</spage><epage>1041.e3</epage><pages>1027-1041.e3</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><coden>JAAPEE</coden><abstract>Objective Adult major depressive disorder (MDD) is associated with reduced cortico-limbic functional connectivity thought to indicate decreased top-down control of emotion. However, it is unclear whether such connectivity alterations are also present in early-childhood–onset MDD. Method A total of 51 children 7 through 11 years of age who had been prospectively studied since preschool age, completed resting state functional magnetic resonance imaging (fMRI) and were assigned to one of four groups: 1) C-MDD (N = 13), those children with a personal history of early-childhood–onset MDD; 2) M-MDD (N = 11), those with a maternal history of affective disorders; 3) CM-MDD (N = 13), those with both maternal and early-childhood–onset MDD; or 4) CON (N = 14), those without either a personal or maternal history of MDD. We used seed-based resting state functional connectivity (rsfcMRI) analysis in an independent sample of adults to identify networks showing both positive (e.g., limbic regions) and negative (e.g., dorsal frontal/parietal regions) connectivity with the amygdala. These regions were then used in region-of-interest–based analyses of our child sample. Results We found a significant interaction between maternal affective disorder history and the child's MDD history for both positive and negative rsfcMRI networks. Specifically, when compared with CON, we found reduced connectivity between the amygdala and the “negative network” in children with C-MDD, M-MDD, and CM-MDD. Children with either C-MDD or a maternal history of MDD (but not CM-MDD) displayed reduced connectivity between the amygdala and the “positive network.” Conclusions Our finding of an attenuated relationship between the amygdala, a region affected in MDD and involved in emotion processing, and cognitive control regions is consistent with a hypothesis of altered regulation of emotional processing in C-MDD, suggesting developmental continuity of this alteration into early childhood.</abstract><cop>Maryland Heights, MO</cop><pub>Elsevier Inc</pub><pmid>21961777</pmid><doi>10.1016/j.jaac.2011.07.019</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-8567 |
| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 2011-10, Vol.50 (10), p.1027-1041.e3 |
| issn | 0890-8567 1527-5418 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3185293 |
| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Access via ScienceDirect (Elsevier) |
| subjects | Adult Adult and adolescent clinical studies Affective disorders Age of Onset amygdala Amygdala - physiopathology Biological and medical sciences Brain Hemisphere Functions Cerebral Cortex - physiopathology Child Child clinical studies Child psychology childhood-onset Children Cognitive Processes Correlation Depression Depression (Psychology) Depressive Disorder, Major - classification Depressive Disorder, Major - diagnosis Depressive Disorder, Major - physiopathology Depressive personality disorders Developmental Continuity Diagnostic Tests Disease Susceptibility Emotions Female fMRI Follow-Up Studies Functional connectivity Humans Limbic System - physiopathology Magnetic Resonance Imaging Male Medical sciences Mental depression Mood disorders Mothers Mothers - psychology Nerve Net - physiopathology NMR Nuclear magnetic resonance Pediatrics Preschool children Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Resting Risk Self Control Severity of Illness Index Sexual Abuse Young Children |
| title | Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T00%3A03%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20Connectivity%20of%20the%20Amygdala%20in%20Early-Childhood-Onset%20Depression&rft.jtitle=Journal%20of%20the%20American%20Academy%20of%20Child%20and%20Adolescent%20Psychiatry&rft.au=Luking,%20Katherine%20R.,%20B.S&rft.date=2011-10-01&rft.volume=50&rft.issue=10&rft.spage=1027&rft.epage=1041.e3&rft.pages=1027-1041.e3&rft.issn=0890-8567&rft.eissn=1527-5418&rft.coden=JAAPEE&rft_id=info:doi/10.1016/j.jaac.2011.07.019&rft_dat=%3Cproquest_pubme%3E896241764%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=896914286&rft_id=info:pmid/21961777&rft_ericid=EJ941614&rft_els_id=1_s2_0_S0890856711006496&rfr_iscdi=true |