Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma

Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer cells with an immature stem-like phenotype are hypothesised to play a role in r...

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Veröffentlicht in:	Acta neuropathologica 2011-10, Vol.122 (4), p.495-510
Hauptverfasser:	Svendsen, Agnete, Verhoeff, Joost J. C., Immervoll, Heike, Brøgger, Jan C., Kmiecik, Justyna, Poli, Aurelie, Netland, Inger A., Prestegarden, Lars, Planagumà, Jesús, Torsvik, Anja, Kjersem, Anneli Bohne, Sakariassen, Per Ø., Heggdal, Jan I., Van Furth, Wouter R., Bjerkvig, Rolf, Lund-Johansen, Morten, Enger, Per Ø., Felsberg, Joerg, Brons, Nicolaas H. C., Tronstad, Karl J., Waha, Andreas, Chekenya, Martha
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens - biosynthesis Antigens - genetics Antigens - radiation effects Antioxidants Biomarkers, Tumor - metabolism Biomarkers, Tumor - radiation effects Biopsy Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cancer Cell cycle Cell survival Chemotherapy DNA damage DNA Damage - genetics DNA Damage - radiation effects DNA methylation DNA repair Enzymes Female Glioblastoma Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - radiotherapy Growth rate Humans Male Medicine Medicine & Public Health Middle Aged Nestin Neuropathology Neurosciences Neurosurgery O6-methylguanine-DNA methyltransferase Oncology Original Paper Oxidative stress Pathology Patients Predictive Value of Tests Prognosis Promoters Proteoglycans - biosynthesis Proteoglycans - genetics Proteoglycans - radiation effects proteomics Radiation therapy Radiation Tolerance Radiation, Ionizing Radioresistance Radiotherapy Stem cells Stem Cells - metabolism Stem Cells - pathology Stem Cells - radiation effects Survival Rate - trends Vimentin
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