Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice

[Display omitted] ► An early treatment with enalapril was performed in exercised mdx mice. ► In vivo, enalapril increased mouse fore limb strength dose-dependently. ► Ex vivo, enalapril reduced muscular markers of oxidative stress and inflammation. ► Results corroborate an early role of angiotensin...

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Veröffentlicht in:	Pharmacological research 2011-11, Vol.64 (5), p.482-492
Hauptverfasser:	Cozzoli, Anna, Nico, Beatrice, Sblendorio, Valeriana Teresa, Capogrosso, Roberta Francesca, Dinardo, Maria Maddalena, Longo, Vito, Gagliardi, Sara, Montagnani, Monica, De Luca, Annamaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - immunology Angiotensin-Converting Enzyme Inhibitors - immunology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Angiotensin-II Animals Enalapril - immunology Enalapril - therapeutic use Humans Inflammation Male Mice Mice, Inbred mdx Muscle, Skeletal - drug effects Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular dystrophy Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - immunology Muscular Dystrophy, Duchenne - metabolism Muscular Dystrophy, Duchenne - pathology Oxidative Stress Pre-clinical pharmacological tests
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