N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester

Ubiquitin thioester is a key intermediate in the ubiquitylation of proteins and is formed enzymatically through the activation of alpha-COOH of ubiquitin in an ATP dependent manner using the E1 enzyme. The current methods used for the preparation of ubiquitin thioester rely on either the enzymatic m...

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Veröffentlicht in:	Organic & biomolecular chemistry 2010-01, Vol.8 (10), p.2392-2396
Hauptverfasser:	Erlich, Lesly A, Kumar, K S Ajish, Haj-Yahya, Mahmood, Dawson, Philip E, Brik, Ashraf
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chromatography, High Pressure Liquid Cysteine - analogs & derivatives Cysteine - chemistry Dendrimers - chemistry Glycopeptides - chemical synthesis Glycopeptides - chemistry Molecular Sequence Data Ubiquitin - chemical synthesis Ubiquitin - chemistry Ubiquitins - chemical synthesis Ubiquitins - chemistry
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