PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3

Mutations of the PITX2 gene cause Axenfeld-Rieger syndrome (ARS) and glaucoma. In this study, the authors investigated genes directly regulated by the PITX2 transcription factor to gain insight into the mechanisms underlying these disorders. RNA from nonpigmented ciliary epithelium cells transfected...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2011-09, Vol.52 (10), p.7625-7633
Hauptverfasser:	Strungaru, M Hermina, Footz, Tim, Liu, Yi, Berry, Fred B, Belleau, Pascal, Semina, Elena V, Raymond, Vincent, Walter, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival Cells, Cultured Gene Expression Regulation - physiology Homeobox Protein PITX2 Homeodomain Proteins - physiology Humans Hydrogen Peroxide - toxicity In Situ Hybridization Oligonucleotide Array Sequence Analysis Organic Anion Transporters, Sodium-Dependent - genetics Oxidative Stress - physiology Plasmids Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - pharmacology Symporters - genetics Trabecular Meshwork - metabolism Transcription Factors - physiology Transcriptional Activation Transfection Zebrafish - embryology
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