The influence of alloxan-induced diabetes on Müller cell contraction-promoting activities in vitreous

Previous studies from this laboratory revealed that vitreous insulin-like growth factor biological activity increases in diabetes and that this change can precede the onset of proliferative diabetic retinopathy. The goal of this study was to characterize this phenomenon in an animal model of alloxan...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2011-09, Vol.52 (10), p.7485-7491
Hauptverfasser:	King, Jeffery L, Mason, 3rd, John O, Cartner, Samuel C, Guidry, Clyde
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan - toxicity Animals Blood Glucose - metabolism Blotting, Western Carbonic Anhydrase I - metabolism Carbonic Anhydrase II - metabolism Diabetes Mellitus, Experimental - metabolism Diabetic Retinopathy - metabolism Fluorescent Antibody Technique, Indirect Glial Fibrillary Acidic Protein - metabolism Hyperglycemia - metabolism Insulin-Like Growth Factor Binding Proteins - metabolism Male Neuroglia - metabolism Real-Time Polymerase Chain Reaction Retina - pathology Swine Vitreous Body - metabolism
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