Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia
We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART) to determine the impact of neuropsychiatric symptoms and socioeconomic status on adherence and mortality. Almost 60% had good adherence based upon pharmacy records. Poor adherence was associated with being...
Gespeichert in:
| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2011-10, Vol.85 (4), p.782-789 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 789 |
|---|---|
| container_issue | 4 |
| container_start_page | 782 |
| container_title | The American journal of tropical medicine and hygiene |
| container_volume | 85 |
| creator | BIRBECK, Gretchen L KVALSUND, Michelle P MALAMA, Costantine BYERS, Peter A BRADBURY, Richard MANG'OMBE, Charles ORGANEK, Natalie KAILE, Trevor SINYAMA, Alex M SINYANGWE, Sylvester S MALAMA, Kennedy |
| description | We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART) to determine the impact of neuropsychiatric symptoms and socioeconomic status on adherence and mortality. Almost 60% had good adherence based upon pharmacy records. Poor adherence was associated with being divorced, poorer, food insecure, and less educated. Longer travel time to clinic, concealing one's human immunodeficiency virus (HIV) status, and experiencing side effects predicted poor adherence. Over a third of the patients had cognitive impairment and poorer cognitive function was also associated with poor adherence. During follow-up (mean 275 days), 20% died-usually within 90 days of starting ART. Neuropsychiatric symptoms, advanced HIV, peripheral neuropathy symptoms, food insecurity, and poverty were associated with death. Neuropsychiatric symptoms, advanced HIV, and poverty remained significant independent predictors of death in a multivariate model adjusting for other significant factors. Social, economic, cognitive, and psychiatric problems impact adherence and survival for people receiving ART in rural Zambia. |
| doi_str_mv | 10.4269/ajtmh.2011.11-0187 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3183792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902812822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-4e70f761482de1eae191db2d991e27be370c8a3d8a8be0611a06ee7dbfd3e6963</originalsourceid><addsrcrecordid>eNp9kc1v1DAQxS0EotvCP8AB5YLoJYvHyfrjgrSq-KhUQKJw4WJNnNmuqyRebKfS_vck26XABWkkS-Pfe3qjx9gL4MtaSPMGb3O_XQoOsAQoOWj1iC2gVrIEWa8eswXnXJRGVuqEnaZ0yydEADxlJwKMkiutFuzmM40x7NLebT3m6F2BQ1tcB-cDuTCEftpcZ8xjKi77HbpcrIfsI-UY7nzErli3W4o0ODoIP4WYsfN5X_ih-DrOwA_sG4_P2JMNdomeH98z9v39u28XH8urLx8uL9ZXpatlncuaFN8oCbUWLQEhgYG2Ea0xQEI1VCnuNFatRt0QlwDIJZFqm01bkZxOPWNv7313Y9NT62jIUwi7i77HuLcBvf33Z_BbexPubAW6UkZMBq-PBjH8HCll2_vkqOtwoDAma7jQILSYyfP_ksChBm7MIZW4R10MKUXaPAQCbucu7aFLO3dpp5m7nEQv_z7lQfK7vAl4dQQwOew2EQfn0x-uXhkj9Kr6BS7_q4Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1014109996</pqid></control><display><type>article</type><title>Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>BIRBECK, Gretchen L ; KVALSUND, Michelle P ; MALAMA, Costantine ; BYERS, Peter A ; BRADBURY, Richard ; MANG'OMBE, Charles ; ORGANEK, Natalie ; KAILE, Trevor ; SINYAMA, Alex M ; SINYANGWE, Sylvester S ; MALAMA, Kennedy</creator><creatorcontrib>BIRBECK, Gretchen L ; KVALSUND, Michelle P ; MALAMA, Costantine ; BYERS, Peter A ; BRADBURY, Richard ; MANG'OMBE, Charles ; ORGANEK, Natalie ; KAILE, Trevor ; SINYAMA, Alex M ; SINYANGWE, Sylvester S ; MALAMA, Kennedy</creatorcontrib><description>We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART) to determine the impact of neuropsychiatric symptoms and socioeconomic status on adherence and mortality. Almost 60% had good adherence based upon pharmacy records. Poor adherence was associated with being divorced, poorer, food insecure, and less educated. Longer travel time to clinic, concealing one's human immunodeficiency virus (HIV) status, and experiencing side effects predicted poor adherence. Over a third of the patients had cognitive impairment and poorer cognitive function was also associated with poor adherence. During follow-up (mean 275 days), 20% died-usually within 90 days of starting ART. Neuropsychiatric symptoms, advanced HIV, peripheral neuropathy symptoms, food insecurity, and poverty were associated with death. Neuropsychiatric symptoms, advanced HIV, and poverty remained significant independent predictors of death in a multivariate model adjusting for other significant factors. Social, economic, cognitive, and psychiatric problems impact adherence and survival for people receiving ART in rural Zambia.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2011.11-0187</identifier><identifier>PMID: 21976587</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Deerfield, IL: American Society of Tropical Medecine and Hygiene</publisher><subject>Adult ; Biological and medical sciences ; HIV Infections - drug therapy ; HIV Infections - mortality ; Humans ; Infectious diseases ; Medical sciences ; Patient Compliance ; Prospective Studies ; Social Class ; Zambia - epidemiology</subject><ispartof>The American journal of tropical medicine and hygiene, 2011-10, Vol.85 (4), p.782-789</ispartof><rights>2015 INIST-CNRS</rights><rights>The American Society of Tropical Medicine and Hygiene 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-4e70f761482de1eae191db2d991e27be370c8a3d8a8be0611a06ee7dbfd3e6963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183792/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183792/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24599285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21976587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BIRBECK, Gretchen L</creatorcontrib><creatorcontrib>KVALSUND, Michelle P</creatorcontrib><creatorcontrib>MALAMA, Costantine</creatorcontrib><creatorcontrib>BYERS, Peter A</creatorcontrib><creatorcontrib>BRADBURY, Richard</creatorcontrib><creatorcontrib>MANG'OMBE, Charles</creatorcontrib><creatorcontrib>ORGANEK, Natalie</creatorcontrib><creatorcontrib>KAILE, Trevor</creatorcontrib><creatorcontrib>SINYAMA, Alex M</creatorcontrib><creatorcontrib>SINYANGWE, Sylvester S</creatorcontrib><creatorcontrib>MALAMA, Kennedy</creatorcontrib><title>Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART) to determine the impact of neuropsychiatric symptoms and socioeconomic status on adherence and mortality. Almost 60% had good adherence based upon pharmacy records. Poor adherence was associated with being divorced, poorer, food insecure, and less educated. Longer travel time to clinic, concealing one's human immunodeficiency virus (HIV) status, and experiencing side effects predicted poor adherence. Over a third of the patients had cognitive impairment and poorer cognitive function was also associated with poor adherence. During follow-up (mean 275 days), 20% died-usually within 90 days of starting ART. Neuropsychiatric symptoms, advanced HIV, peripheral neuropathy symptoms, food insecurity, and poverty were associated with death. Neuropsychiatric symptoms, advanced HIV, and poverty remained significant independent predictors of death in a multivariate model adjusting for other significant factors. Social, economic, cognitive, and psychiatric problems impact adherence and survival for people receiving ART in rural Zambia.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - mortality</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Patient Compliance</subject><subject>Prospective Studies</subject><subject>Social Class</subject><subject>Zambia - epidemiology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1v1DAQxS0EotvCP8AB5YLoJYvHyfrjgrSq-KhUQKJw4WJNnNmuqyRebKfS_vck26XABWkkS-Pfe3qjx9gL4MtaSPMGb3O_XQoOsAQoOWj1iC2gVrIEWa8eswXnXJRGVuqEnaZ0yydEADxlJwKMkiutFuzmM40x7NLebT3m6F2BQ1tcB-cDuTCEftpcZ8xjKi77HbpcrIfsI-UY7nzErli3W4o0ODoIP4WYsfN5X_ih-DrOwA_sG4_P2JMNdomeH98z9v39u28XH8urLx8uL9ZXpatlncuaFN8oCbUWLQEhgYG2Ea0xQEI1VCnuNFatRt0QlwDIJZFqm01bkZxOPWNv7313Y9NT62jIUwi7i77HuLcBvf33Z_BbexPubAW6UkZMBq-PBjH8HCll2_vkqOtwoDAma7jQILSYyfP_ksChBm7MIZW4R10MKUXaPAQCbucu7aFLO3dpp5m7nEQv_z7lQfK7vAl4dQQwOew2EQfn0x-uXhkj9Kr6BS7_q4Q</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>BIRBECK, Gretchen L</creator><creator>KVALSUND, Michelle P</creator><creator>MALAMA, Costantine</creator><creator>BYERS, Peter A</creator><creator>BRADBURY, Richard</creator><creator>MANG'OMBE, Charles</creator><creator>ORGANEK, Natalie</creator><creator>KAILE, Trevor</creator><creator>SINYAMA, Alex M</creator><creator>SINYANGWE, Sylvester S</creator><creator>MALAMA, Kennedy</creator><general>American Society of Tropical Medecine and Hygiene</general><general>The American Society of Tropical Medicine and Hygiene</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111001</creationdate><title>Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia</title><author>BIRBECK, Gretchen L ; KVALSUND, Michelle P ; MALAMA, Costantine ; BYERS, Peter A ; BRADBURY, Richard ; MANG'OMBE, Charles ; ORGANEK, Natalie ; KAILE, Trevor ; SINYAMA, Alex M ; SINYANGWE, Sylvester S ; MALAMA, Kennedy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-4e70f761482de1eae191db2d991e27be370c8a3d8a8be0611a06ee7dbfd3e6963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - mortality</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Patient Compliance</topic><topic>Prospective Studies</topic><topic>Social Class</topic><topic>Zambia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BIRBECK, Gretchen L</creatorcontrib><creatorcontrib>KVALSUND, Michelle P</creatorcontrib><creatorcontrib>MALAMA, Costantine</creatorcontrib><creatorcontrib>BYERS, Peter A</creatorcontrib><creatorcontrib>BRADBURY, Richard</creatorcontrib><creatorcontrib>MANG'OMBE, Charles</creatorcontrib><creatorcontrib>ORGANEK, Natalie</creatorcontrib><creatorcontrib>KAILE, Trevor</creatorcontrib><creatorcontrib>SINYAMA, Alex M</creatorcontrib><creatorcontrib>SINYANGWE, Sylvester S</creatorcontrib><creatorcontrib>MALAMA, Kennedy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BIRBECK, Gretchen L</au><au>KVALSUND, Michelle P</au><au>MALAMA, Costantine</au><au>BYERS, Peter A</au><au>BRADBURY, Richard</au><au>MANG'OMBE, Charles</au><au>ORGANEK, Natalie</au><au>KAILE, Trevor</au><au>SINYAMA, Alex M</au><au>SINYANGWE, Sylvester S</au><au>MALAMA, Kennedy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>85</volume><issue>4</issue><spage>782</spage><epage>789</epage><pages>782-789</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>We conducted a prospective cohort study of 496 adults starting antiretroviral treatment (ART) to determine the impact of neuropsychiatric symptoms and socioeconomic status on adherence and mortality. Almost 60% had good adherence based upon pharmacy records. Poor adherence was associated with being divorced, poorer, food insecure, and less educated. Longer travel time to clinic, concealing one's human immunodeficiency virus (HIV) status, and experiencing side effects predicted poor adherence. Over a third of the patients had cognitive impairment and poorer cognitive function was also associated with poor adherence. During follow-up (mean 275 days), 20% died-usually within 90 days of starting ART. Neuropsychiatric symptoms, advanced HIV, peripheral neuropathy symptoms, food insecurity, and poverty were associated with death. Neuropsychiatric symptoms, advanced HIV, and poverty remained significant independent predictors of death in a multivariate model adjusting for other significant factors. Social, economic, cognitive, and psychiatric problems impact adherence and survival for people receiving ART in rural Zambia.</abstract><cop>Deerfield, IL</cop><pub>American Society of Tropical Medecine and Hygiene</pub><pmid>21976587</pmid><doi>10.4269/ajtmh.2011.11-0187</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9637 |
| ispartof | The American journal of tropical medicine and hygiene, 2011-10, Vol.85 (4), p.782-789 |
| issn | 0002-9637 1476-1645 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3183792 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences HIV Infections - drug therapy HIV Infections - mortality Humans Infectious diseases Medical sciences Patient Compliance Prospective Studies Social Class Zambia - epidemiology |
| title | Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T17%3A11%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuropsychiatric%20and%20Socioeconomic%20Status%20Impact%20Antiretroviral%20Adherence%20and%20Mortality%20in%20Rural%20Zambia&rft.jtitle=The%20American%20journal%20of%20tropical%20medicine%20and%20hygiene&rft.au=BIRBECK,%20Gretchen%20L&rft.date=2011-10-01&rft.volume=85&rft.issue=4&rft.spage=782&rft.epage=789&rft.pages=782-789&rft.issn=0002-9637&rft.eissn=1476-1645&rft.coden=AJTHAB&rft_id=info:doi/10.4269/ajtmh.2011.11-0187&rft_dat=%3Cproquest_pubme%3E902812822%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1014109996&rft_id=info:pmid/21976587&rfr_iscdi=true |