Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial–mesenchymal transition, and cancer stem cell properties

Six1 is a critical regulator of embryonic development that requires interaction with the Eya family of proteins (Eya1-4) to activate the transcription of genes involved in neurogenesis, myogenesis and nephrogenesis. Although expression of Six1 and Eya family members is predominantly observed in deve...

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Veröffentlicht in:	Oncogene 2012-02, Vol.31 (5), p.552-562
Hauptverfasser:	Farabaugh, S M, Micalizzi, D S, Jedlicka, P, Zhao, R, Ford, H L
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma Cell Biology Cell Line, Tumor Data processing Development and progression Embryogenesis Epithelial-Mesenchymal Transition Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Genetics Humans Immunohistochemistry Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kaplan-Meier Estimate Mammary gland Medicine Medicine & Public Health Metastases Metastasis myogenesis Neoplasm Metastasis Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neurogenesis Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology original-article Prognosis Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Protein-protein interactions Proteins Reverse Transcriptase Polymerase Chain Reaction RNA Interference Side effects Signal Transduction Stem cells Tissue Array Analysis Transcription Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor- beta Transforming growth factors Tumors
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