Pituitary Adenylate Cyclase-Activating Polypeptide Controls Stimulus-Transcription Coupling in the Hypothalamic-Pituitary-Adrenal Axis to Mediate Sustained Hormone Secretion During Stress

External and internal stimuli that threaten homeostasis trigger coordinated stress responses through activation of specialised neuroendocrine circuits. In mammals, the hypothalamic‐pituitary‐adrenal (HPA) axis mediates responses to stressors such as restraint, ultimately enhancing adrenocortical hor...

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Veröffentlicht in:	Journal of neuroendocrinology 2011-10, Vol.23 (10), p.944-955
Hauptverfasser:	Stroth, N., Liu, Y., Aguilera, G., Eiden, L. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Animals Biological and medical sciences Circuits Corticosterone Corticotropin-releasing hormone Fundamental and applied biological sciences. Psychology hnRNA Homeostasis Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System Hypothalamus Male Mice Nr4a Nuclear receptors Nur77 protein Nurr1 protein Paraventricular nucleus Pituitary adenylate cyclase-activating polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide - physiology Pituitary Hormones - metabolism Pituitary-Adrenal System Polymerase Chain Reaction Secretion Steroid 21-hydroxylase steroidogenic factor 1 Stress Stress, Psychological Transcription factors Transcription, Genetic - physiology Vertebrates: endocrinology
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