Expression of histone deacetylases in lymphoma: implication for the development of selective inhibitors

Summary Unselective histone deacetylase (HDAC) inhibitors are a promising novel therapy for lymphoid malignancies. However, these treatments remain empiric as the pattern of HDAC enzymes in different types of cancer, including lymphoid malignancies, remains unknown. We examined the expression of cla...

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Veröffentlicht in:	British journal of haematology 2009-11, Vol.147 (4), p.515-525
Hauptverfasser:	Gloghini, Annunziata, Buglio, Daniela, Khaskhely, Noor M., Georgakis, Georgios, Orlowski, Robert Z., Neelapu, Sattva S., Carbone, Antonino, Younes, Anas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic Agents - pharmacology Biological and medical sciences Biomarkers, Tumor - metabolism Cell Proliferation - drug effects gene expression profile HDAC HDAC inhibitors Hematologic and hematopoietic diseases Histone Deacetylase 6 Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histone Deacetylases - physiology Hodgkin Disease - enzymology Hodgkin Disease - pathology Hodgkin lymphoma Humans Isoenzymes - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - enzymology Medical sciences Neoplasm Proteins - metabolism Reed Sternberg cells Reed-Sternberg Cells - enzymology Tubulin - metabolism Tumor Cells, Cultured
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