Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells

The cumulative exposure to estrogens is an important determinant in the risk of breast cancer, yet the full range of mechanisms involving estrogens in the genesis and progression of breast cancer remains a subject of debate. Interactions of estrogens and environmental toxicants have received attenti...

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Veröffentlicht in:	Toxicology and applied pharmacology 2009-11, Vol.240 (3), p.355-366
Hauptverfasser:	Spink, Barbara C., Bennett, James A., Pentecost, Brian T., Lostritto, Nicole, Englert, Neal A., Benn, Geoffrey K., Goodenough, Angela K., Turesky, Robert J., Spink, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMALS Aryl Hydrocarbon Hydroxylases - genetics Base Sequence Benzo( a)pyrene Biological and medical sciences BIOLOGICAL EFFECTS Biotransformation BODY Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology CARCINOGENESIS Carcinogenesis, carcinogens and anticarcinogens CARCINOGENS Carcinogens - pharmacokinetics Cell Line, Tumor Chemical agents Chromatography, Liquid Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1B1 DISEASES DNA Adducts DNA Primers ESTRADIOL Estradiol - analogs & derivatives Estradiol - pharmacology ESTRANES Estrogen Receptor Modulators - pharmacology ESTROGENS Estrogens - administration & dosage Estrogens - pharmacology Female Gene Expression Regulation, Neoplastic - drug effects GENES GENETIC EFFECTS GLANDS Gynecology. Andrology. Obstetrics HORMONES Humans HYDROXY COMPOUNDS Long-term estrogen exposure MALES MAMMALS Mammary gland diseases MAMMARY GLANDS MAN MCF-7 cells Medical sciences MEN NEOPLASMS ORGANIC COMPOUNDS ORGANS PATHOGENESIS PRIMATES Promoter Regions, Genetic RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS Reverse Transcriptase Polymerase Chain Reaction Spectrometry, Mass, Electrospray Ionization STEROID HORMONES STEROIDS Tandem Mass Spectrometry Tumors VERTEBRATES
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