The Pyk2 FERM domain as a target to inhibit glioma migration

The invasion of malignant glioma cells into the surrounding normal brain precludes effective clinical treatment. In this report, we investigated the role of the NH 2 -terminal FERM domain in the regulation of the promigratory function of Pyk2. We report that the substitution of residues that constit...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-06, Vol.8 (6), p.1505-1514
Hauptverfasser:	Loftus, Joseph C, Yang, Zhongbo, Tran, Nhan L, Kloss, Jean, Viso, Carole, Berens, Michael E, Lipinski, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Base Sequence Binding Sites - genetics Binding Sites - immunology Cell Line Cell Line, Tumor Cell Movement - drug effects Epitopes - chemistry Epitopes - metabolism Female focal adhesion kinase Focal Adhesion Kinase 2 - chemistry Focal Adhesion Kinase 2 - genetics Focal Adhesion Kinase 2 - metabolism glioma Glioma - drug therapy Glioma - metabolism Glioma - pathology Humans Immunoblotting Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism invasion Mice Mice, Inbred BALB C Mice, Nude Models, Molecular Molecular Sequence Data Phosphorylation Protein Binding Protein Structure, Tertiary Pyk2 single-chain Fv Xenograft Model Antitumor Assays
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