Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor
This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizat...
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| Veröffentlicht in: | Drug design, development and therapy development and therapy, 2011, Vol.5, p.407-409 |
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| creator | Avramova, Boryana E Yordanova, Maya N Konstantinov, Dobrin N Bobev, Dragan G |
| description | This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure. |
| doi_str_mv | 10.2147/DDDT.S19157 |
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A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure.</description><identifier>ISSN: 1177-8881</identifier><identifier>EISSN: 1177-8881</identifier><identifier>DOI: 10.2147/DDDT.S19157</identifier><identifier>PMID: 21966213</identifier><language>eng</language><publisher>New Zealand: Taylor & Francis Ltd</publisher><subject>Adolescent ; Antigens, CD34 - metabolism ; Autografts ; Blood ; Blood Cell Count ; CD34 antigen ; Child ; Children ; Colonies ; Colony-stimulating factor ; G-CSF ; Granulocyte colony-stimulating factor ; Granulocyte Colony-Stimulating Factor - administration & dosage ; Granulocytes ; Hematopoietic Stem Cell Mobilization - adverse effects ; Hematopoietic Stem Cell Mobilization - methods ; Hematopoietic stem cells ; Heterocyclic Compounds - administration & dosage ; Heterocyclic Compounds - adverse effects ; Humans ; Leukapheresis ; Leukapheresis - methods ; Leukocytes (granulocytic) ; Male ; mobilization ; Neoplasms - therapy ; Original Research ; Peripheral blood ; Peripheral Blood Stem Cell Transplantation - methods ; plerixafor ; Stem cells ; Transplantation ; Transplantation, Autologous ; Treatment Outcome</subject><ispartof>Drug design, development and therapy, 2011, Vol.5, p.407-409</ispartof><rights>2011. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2011 Avramova et al, publisher and licensee Dove Medical Press Ltd. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-9e85d590c7f2e89b7b648a5e25dd2b7eb762a97419a42e54f739b3b5d9a685a73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180515/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180515/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,3862,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21966213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avramova, Boryana E</creatorcontrib><creatorcontrib>Yordanova, Maya N</creatorcontrib><creatorcontrib>Konstantinov, Dobrin N</creatorcontrib><creatorcontrib>Bobev, Dragan G</creatorcontrib><title>Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor</title><title>Drug design, development and therapy</title><addtitle>Drug Des Devel Ther</addtitle><description>This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure.</description><subject>Adolescent</subject><subject>Antigens, CD34 - metabolism</subject><subject>Autografts</subject><subject>Blood</subject><subject>Blood Cell Count</subject><subject>CD34 antigen</subject><subject>Child</subject><subject>Children</subject><subject>Colonies</subject><subject>Colony-stimulating factor</subject><subject>G-CSF</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Granulocyte Colony-Stimulating Factor - administration & dosage</subject><subject>Granulocytes</subject><subject>Hematopoietic Stem Cell Mobilization - adverse effects</subject><subject>Hematopoietic Stem Cell Mobilization - methods</subject><subject>Hematopoietic stem cells</subject><subject>Heterocyclic Compounds - administration & dosage</subject><subject>Heterocyclic Compounds - adverse effects</subject><subject>Humans</subject><subject>Leukapheresis</subject><subject>Leukapheresis - methods</subject><subject>Leukocytes (granulocytic)</subject><subject>Male</subject><subject>mobilization</subject><subject>Neoplasms - therapy</subject><subject>Original Research</subject><subject>Peripheral blood</subject><subject>Peripheral Blood Stem Cell Transplantation - methods</subject><subject>plerixafor</subject><subject>Stem cells</subject><subject>Transplantation</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><issn>1177-8881</issn><issn>1177-8881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkU1vFSEYhYnR2A9duTckbjRmWmCGATYmptevpMZF65owzDv30jAwwkz19m_0D8vNrbVlA4FznjeHg9ArSk4YbcTparW6PLmginLxBB1SKkQlpaRPH5wP0FHOV4S0dcvIc3TAqGpbRutDdHuxWAs5D4vHY-ycdzdmdjHgOOAJkps2kIzHnY-xx3mGEVvwPmMXsN043ycI-LebN9iaYCHhJbuwxpMv1j9miAm__R5vdtx32IQer5MJi492O0Nlo49hW6BuXHwZWnyDsXNML9CzwfgML-_2Y_Tz86fLs6_V-Y8v384-nle2aeRcKZC854pYMTCQqhNd20jDgfG-Z52ATrTMKNFQZRoGvBlErbq6470yreRG1Mfow547Ld0IvYUwl6x6Sm40aaujcfrxS3AbvY7XuqaScMoL4HQP6OM1TKl84yPz_1sbRy0pl8Xx5m5kir8WyLO-iksKJaVmu6U4UaSo3u9VNsWcEwz3WEr0rnO961zvOy_q1w9j3Gv_lVz_Bf89rTI</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Avramova, Boryana E</creator><creator>Yordanova, Maya N</creator><creator>Konstantinov, Dobrin N</creator><creator>Bobev, Dragan G</creator><general>Taylor & Francis Ltd</general><general>Dove Press</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>2011</creationdate><title>Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor</title><author>Avramova, Boryana E ; Yordanova, Maya N ; Konstantinov, Dobrin N ; Bobev, Dragan G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-9e85d590c7f2e89b7b648a5e25dd2b7eb762a97419a42e54f739b3b5d9a685a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Antigens, CD34 - metabolism</topic><topic>Autografts</topic><topic>Blood</topic><topic>Blood Cell Count</topic><topic>CD34 antigen</topic><topic>Child</topic><topic>Children</topic><topic>Colonies</topic><topic>Colony-stimulating factor</topic><topic>G-CSF</topic><topic>Granulocyte colony-stimulating factor</topic><topic>Granulocyte Colony-Stimulating Factor - administration & dosage</topic><topic>Granulocytes</topic><topic>Hematopoietic Stem Cell Mobilization - adverse effects</topic><topic>Hematopoietic Stem Cell Mobilization - methods</topic><topic>Hematopoietic stem cells</topic><topic>Heterocyclic Compounds - administration & dosage</topic><topic>Heterocyclic Compounds - adverse effects</topic><topic>Humans</topic><topic>Leukapheresis</topic><topic>Leukapheresis - methods</topic><topic>Leukocytes (granulocytic)</topic><topic>Male</topic><topic>mobilization</topic><topic>Neoplasms - therapy</topic><topic>Original Research</topic><topic>Peripheral blood</topic><topic>Peripheral Blood Stem Cell Transplantation - methods</topic><topic>plerixafor</topic><topic>Stem cells</topic><topic>Transplantation</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avramova, Boryana E</creatorcontrib><creatorcontrib>Yordanova, Maya N</creatorcontrib><creatorcontrib>Konstantinov, Dobrin N</creatorcontrib><creatorcontrib>Bobev, Dragan G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug design, development and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avramova, Boryana E</au><au>Yordanova, Maya N</au><au>Konstantinov, Dobrin N</au><au>Bobev, Dragan G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor</atitle><jtitle>Drug design, development and therapy</jtitle><addtitle>Drug Des Devel Ther</addtitle><date>2011</date><risdate>2011</risdate><volume>5</volume><spage>407</spage><epage>409</epage><pages>407-409</pages><issn>1177-8881</issn><eissn>1177-8881</eissn><abstract>This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure.</abstract><cop>New Zealand</cop><pub>Taylor & Francis Ltd</pub><pmid>21966213</pmid><doi>10.2147/DDDT.S19157</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antigens, CD34 - metabolism Autografts Blood Blood Cell Count CD34 antigen Child Children Colonies Colony-stimulating factor G-CSF Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - administration & dosage Granulocytes Hematopoietic Stem Cell Mobilization - adverse effects Hematopoietic Stem Cell Mobilization - methods Hematopoietic stem cells Heterocyclic Compounds - administration & dosage Heterocyclic Compounds - adverse effects Humans Leukapheresis Leukapheresis - methods Leukocytes (granulocytic) Male mobilization Neoplasms - therapy Original Research Peripheral blood Peripheral Blood Stem Cell Transplantation - methods plerixafor Stem cells Transplantation Transplantation, Autologous Treatment Outcome |
| title | Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor |
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