Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that promotes the transcription of cytoprotective genes in response to oxidative and electrophilic stresses. Most functions of Nrf2 were identified by studying biological models with Nrf2 deficiency, however, little is know...

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Veröffentlicht in:	Toxicological sciences 2011-10, Vol.123 (2), p.590-600
Hauptverfasser:	Wu, Kai Connie, Cui, Julia Yue, Klaassen, Curtis D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - metabolism Gene Dosage Gene Expression Profiling Gene Expression Regulation, Enzymologic Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout NADP - genetics NADP - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oligonucleotide Array Sequence Analysis RNA, Messenger - metabolism Systems Toxicology Transcription, Genetic
Online-Zugang:	Volltext
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