Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats : A Model of Type 2 Diabetes
Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Meth...
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| Veröffentlicht in: | Experimental diabetes research 2011-01, Vol.2011 (2011), p.1-11 |
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| creator | Kitada, Munehiro Takeda, Ai Nagai, Takako Ito, Hiroki Kanasaki, Keizo Koya, Daisuke |
| description | Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-κB (p65), Sirt1 protein expression, and p62/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated. Results. DR ameliorated renal abnormalities including inflammation in WFRs. The decrease in Sirt1 levels, increase in acetylated-NF-κB, and impaired autophagy in WFRs were improved by DR. Conclusions. DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes. |
| doi_str_mv | 10.1155/2011/908185 |
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Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-κB (p65), Sirt1 protein expression, and p62/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated. Results. DR ameliorated renal abnormalities including inflammation in WFRs. The decrease in Sirt1 levels, increase in acetylated-NF-κB, and impaired autophagy in WFRs were improved by DR. Conclusions. DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.</description><identifier>ISSN: 1687-5214</identifier><identifier>EISSN: 1687-5303</identifier><identifier>DOI: 10.1155/2011/908185</identifier><identifier>PMID: 21949662</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Albuminuria ; Animals ; Autophagy ; Diabetes Mellitus, Type 2 - complications ; Diabetic Nephropathies - diet therapy ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; Diet, Reducing ; Fibrosis ; Inflammation - diet therapy ; Inflammation - metabolism ; Kidney - chemistry ; Kidney - metabolism ; Kidney - pathology ; Macrophages - pathology ; Male ; Rats ; Rats, Wistar ; Sirtuin 1 - analysis</subject><ispartof>Experimental diabetes research, 2011-01, Vol.2011 (2011), p.1-11</ispartof><rights>Copyright © 2011 Munehiro Kitada et al.</rights><rights>Copyright © 2011 Munehiro Kitada et al. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-e60e89a58fac46d012a5f269241fa4148b2f368e22293f959b22bf894144aeb13</citedby><cites>FETCH-LOGICAL-c503t-e60e89a58fac46d012a5f269241fa4148b2f368e22293f959b22bf894144aeb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21949662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kurtz, Theodore W.</contributor><creatorcontrib>Kitada, Munehiro</creatorcontrib><creatorcontrib>Takeda, Ai</creatorcontrib><creatorcontrib>Nagai, Takako</creatorcontrib><creatorcontrib>Ito, Hiroki</creatorcontrib><creatorcontrib>Kanasaki, Keizo</creatorcontrib><creatorcontrib>Koya, Daisuke</creatorcontrib><title>Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats : A Model of Type 2 Diabetes</title><title>Experimental diabetes research</title><addtitle>Exp Diabetes Res</addtitle><description>Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-κB (p65), Sirt1 protein expression, and p62/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated. Results. DR ameliorated renal abnormalities including inflammation in WFRs. The decrease in Sirt1 levels, increase in acetylated-NF-κB, and impaired autophagy in WFRs were improved by DR. Conclusions. DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.</description><subject>Albuminuria</subject><subject>Animals</subject><subject>Autophagy</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Nephropathies - diet therapy</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diet, Reducing</subject><subject>Fibrosis</subject><subject>Inflammation - diet therapy</subject><subject>Inflammation - metabolism</subject><subject>Kidney - chemistry</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sirtuin 1 - analysis</subject><issn>1687-5214</issn><issn>1687-5303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EomXhxBnkW4EqrO3EWYcDUtQ_tFIBqRRxjCbZ8cYoiUPsFOVr8onwNtsFTpw80vzmvafxEPKcs7ecS7kUjPNlxhRX8gE55KlaRTJm8cP7WvDkgDxx7jtjSSqlekwOBM-SLE3FIfl1atDDMNFrdH4wlTe2o3mLjbEDeHT01ECJ3lT0E_b1YHvw9UR9qMZNTfPOm-iy0w20LXgbZM60xso7Ct06SG7GBu4UrQ4zSPPR276GzURvDdxZbl12wBczeE5N98fym3EhGz0H7yf6SsNSw2t6DUH-Hc3pR7vGZjt4M_VIxW4M3VPySEPj8NnuXZCv52c3JxfR1ecPlyf5VVRJFvsIU4YqA6k0VEm6ZlyA1CLNRMI1JDxRpdBxqlAIkcU6k1kpRKlVFloJYMnjBXk_6_Zj2eK6ws4P0BT9YNqw0MKCKf7tdKYuNva2iPlK8ZBhQY52AoP9MYZlFK1xFTYNdGhHVwQvxeMkFoE8nslqsM4NqPcunBXbIyi2R1DMRxDol38H27P3vx6ANzNQm24NP81_1F7MMAYENexhyVaCJfFvDz_GRw</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Kitada, Munehiro</creator><creator>Takeda, Ai</creator><creator>Nagai, Takako</creator><creator>Ito, Hiroki</creator><creator>Kanasaki, Keizo</creator><creator>Koya, Daisuke</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats : A Model of Type 2 Diabetes</title><author>Kitada, Munehiro ; Takeda, Ai ; Nagai, Takako ; Ito, Hiroki ; Kanasaki, Keizo ; Koya, Daisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-e60e89a58fac46d012a5f269241fa4148b2f368e22293f959b22bf894144aeb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Albuminuria</topic><topic>Animals</topic><topic>Autophagy</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Nephropathies - diet therapy</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diet, Reducing</topic><topic>Fibrosis</topic><topic>Inflammation - diet therapy</topic><topic>Inflammation - metabolism</topic><topic>Kidney - chemistry</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sirtuin 1 - analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Kitada, Munehiro</creatorcontrib><creatorcontrib>Takeda, Ai</creatorcontrib><creatorcontrib>Nagai, Takako</creatorcontrib><creatorcontrib>Ito, Hiroki</creatorcontrib><creatorcontrib>Kanasaki, Keizo</creatorcontrib><creatorcontrib>Koya, Daisuke</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental diabetes research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitada, Munehiro</au><au>Takeda, Ai</au><au>Nagai, Takako</au><au>Ito, Hiroki</au><au>Kanasaki, Keizo</au><au>Koya, Daisuke</au><au>Kurtz, Theodore W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats : A Model of Type 2 Diabetes</atitle><jtitle>Experimental diabetes research</jtitle><addtitle>Exp Diabetes Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1687-5214</issn><eissn>1687-5303</eissn><abstract>Aim. Despite the beneficial effects of dietary restriction (DR) on lifespan, age-related diseases, including diabetes and cardiovascular diseases, its effects on type 2 diabetic nephropathy remain unknown. This study examined the renoprotective effects of DR in Wistar fatty (fa/fa) rats (WFRs). Methods. WFRs were treated with DR (40% restriction) for 24 weeks. Urinary albumin excretion, creatinine clearance, renal histologies, acetylated-NF-κB (p65), Sirt1 protein expression, and p62/Sqstm 1 accumulation in the renal cortex, as well as electron microscopic observation of mitochondrial morphology and autophagosomes in proximal tubular cells were estimated. Results. DR ameliorated renal abnormalities including inflammation in WFRs. The decrease in Sirt1 levels, increase in acetylated-NF-κB, and impaired autophagy in WFRs were improved by DR. Conclusions. DR exerted anti-inflammatory effects and improved the dysregulation of autophagy through the restoration of Sirt1 in the kidneys of WFRs, which resulted in the amelioration of renal injuries in type 2 diabetes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>21949662</pmid><doi>10.1155/2011/908185</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Albuminuria Animals Autophagy Diabetes Mellitus, Type 2 - complications Diabetic Nephropathies - diet therapy Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Diet, Reducing Fibrosis Inflammation - diet therapy Inflammation - metabolism Kidney - chemistry Kidney - metabolism Kidney - pathology Macrophages - pathology Male Rats Rats, Wistar Sirtuin 1 - analysis |
| title | Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats : A Model of Type 2 Diabetes |
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