Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice

ABSTRACT Sex determination in fetal germ cells depends on a balance between exposure to retinoic acid (RA) and the degradation of RA achieved by the testis‐specific expression of the catabolic cytochrome P450 enzyme, CYP26B1. Therefore, identification of factors regulating the expression of the Cyp2...

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Veröffentlicht in:	The FASEB journal 2011-10, Vol.25 (10), p.3561-3569
Hauptverfasser:	Kashimada, Kenichi, Svingen, Terje, Feng, Chun‐Wei, Pelosi, Emanuele, Bagheri‐Fam, Stefan, Harley, Vincent R., Schlessinger, David, Bowles, Josephine, Koopman, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Forkhead Box Protein L2 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation, Developmental - physiology germ cells Male meiosis Mice Research Communications retinoic acid Retinoic Acid 4-Hydroxylase RNA Splicing Factors sex determination Sex Determination Processes - physiology SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Testis - growth & development Testis - metabolism Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation
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